1.1.1.168: 2-dehydropantolactone reductase (Re-specific)

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For detailed information about 2-dehydropantolactone reductase (Re-specific), go to the full flat file.

Reaction

Synonyms

(R)-pantoyl-lactone:NADP+ oxidoreductase (A-specific), 2-dehydropantoyl-lactone reductase, 2-dehydropantoyl-lactone reductase (A-specific), 2-ketopantoyl lactone reductase, AKR, CPR, ketopantoyl lactone reductase, NADPH-dependent aldo-keto reductase, NADPH-dependent conjugated polyketone reductase, reductase, 2-oxopantoyl lactone

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.168 2-dehydropantolactone reductase (Re-specific)

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Results	in table
4	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
3	Cofactor
1	Crystallization (Commentary)
1	General Stability
42	Inhibitors
3	kcat/KM [mM/s]
1	Ki Value [mM]
32	KM Value [mM]
1	Metals/Ions
5	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
19	Organism
1	Pathway
7	pH Optimum
2	pH Range
3	pH Stability
18	Protein Variants
7	Purification (Commentary)
1	Reaction
3	Reaction Type
16	Reference
6	Specific Activity [micromol/min/mg]
2	Storage Stability
80	Substrates and Products (Substrate)
11	Subunits
22	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
2	Temperature Range [°C]
5	Temperature Stability [°C]
3	Turnover Number [1/s]

Engineering

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Engineering on EC 1.1.1.168 - 2-dehydropantolactone reductase (Re-specific)

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

H128A

Candida dubliniensis

B9WJQ5

the mutant shows strongly reduced activity compared to the wild type enzyme

761008

T30A

Candida dubliniensis

B9WJQ5

the mutant shows reduced activity compared to the wild type enzyme

761008

Y66A

Candida dubliniensis

B9WJQ5

inactive

761008

H128A

Candida dubliniensis ATCC MYA-646

-

the mutant shows strongly reduced activity compared to the wild type enzyme

-

T30A

Candida dubliniensis ATCC MYA-646

-

the mutant shows reduced activity compared to the wild type enzyme

-

Y66A

Candida dubliniensis ATCC MYA-646

-

inactive

-

H128A

Candida dubliniensis CBS 7987

-

the mutant shows strongly reduced activity compared to the wild type enzyme

-

T30A

Candida dubliniensis CBS 7987

-

the mutant shows reduced activity compared to the wild type enzyme

-

Y66A

Candida dubliniensis CBS 7987

-

inactive

-

H128A

Candida dubliniensis CD36

-

the mutant shows strongly reduced activity compared to the wild type enzyme

-

T30A

Candida dubliniensis CD36

-

the mutant shows reduced activity compared to the wild type enzyme

-

Y66A

Candida dubliniensis CD36

-

inactive

-

H128A

Candida dubliniensis NCPF 3949

-

the mutant shows strongly reduced activity compared to the wild type enzyme

-

T30A

Candida dubliniensis NCPF 3949

-

the mutant shows reduced activity compared to the wild type enzyme

-

Y66A

Candida dubliniensis NCPF 3949

-

inactive

-

H128A

Candida dubliniensis NRRL Y-17841

-

the mutant shows strongly reduced activity compared to the wild type enzyme

-

T30A

Candida dubliniensis NRRL Y-17841

-

the mutant shows reduced activity compared to the wild type enzyme

-

Y66A

Candida dubliniensis NRRL Y-17841

-

inactive

-