1.1.1.168: 2-dehydropantolactone reductase (Re-specific)

This is an abbreviated version!
For detailed information about 2-dehydropantolactone reductase (Re-specific), go to the full flat file.

Word Map on EC 1.1.1.168

Reaction

(R)-pantolactone
+
NADP+
=
2-dehydropantolactone
+
NADPH
+
H+

Synonyms

(R)-pantoyl-lactone:NADP+ oxidoreductase (A-specific), 2-dehydropantoyl-lactone reductase, 2-dehydropantoyl-lactone reductase (A-specific), 2-ketopantoyl lactone reductase, AKR, CPR, ketopantoyl lactone reductase, NADPH-dependent aldo-keto reductase, NADPH-dependent conjugated polyketone reductase, reductase, 2-oxopantoyl lactone

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.168 2-dehydropantolactone reductase (Re-specific)

Inhibitors

Inhibitors on EC 1.1.1.168 - 2-dehydropantolactone reductase (Re-specific)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2-Cyclopentanedione
-
-
2-keto-4-hydroxybutyrolactone
-
-
2-Oxo-4-hydroxy-3-methylbutyric acid-gamma-lactone
-
-
2-Oxo-4-hydroxybutyric acid-gamma-lactone
-
-
2-oxoisopentanoic acid
-
-
2-Oxopentanoic acid
-
-
3,4-Dihydroxy-3-cyclobutene-1,2-dione
-
uncompetitive to isatin
Ca2+
94.6% residual activity at 1 mM
iodoacetate
-
-
ketopantoyl lactone
Ni2+
88.5% residual activity at 1 mM
oxopyrrolidines
-
-
p-chloromercuribenzoate
-
-
Polyketones
-
quercetin
Reactive Red 3A
-
-