1.1.1.169: 2-dehydropantoate 2-reductase

This is an abbreviated version!
For detailed information about 2-dehydropantoate 2-reductase, go to the full flat file.

Word Map on EC 1.1.1.169

Reaction

(R)-pantoate
+
NADP+
=
2-dehydropantoate
+
NADPH
+
H+

Synonyms

2-dehydropantoate 2-reductase, 2-ketopantoate reductase, 2-ketopantoic acid reductase, 2-oxopantoate reductase, ilvC, ketopantoate reductase, ketopantoic acid reductase, KPA reductase, KPR, More, panG, Tk-KPR, TK1968, TK1968 protein

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.169 2-dehydropantoate 2-reductase

Engineering

Engineering on EC 1.1.1.169 - 2-dehydropantoate 2-reductase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D248A
E210A
E240A
-
site-directed mutagenesis, wild-type activity
E256A
E256D
-
wild-type activity
K176A
K176A/E256A
-
double mutant, no activity
K176C
-
wild-type activity
R31A
site-directed mutagenesis, altered steady-state kinetics of the mutant compared to the wild-type enzyme, overview
S244A
A181L
W129A
site-directed mutagenesis
Y60A
site-directed mutagenesis
W129A
-
site-directed mutagenesis
-
Y60A
-
site-directed mutagenesis
-
additional information