1.1.1.174: cyclohexane-1,2-diol dehydrogenase

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For detailed information about cyclohexane-1,2-diol dehydrogenase, go to the full flat file.

Reaction

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.174 cyclohexane-1,2-diol dehydrogenase

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Results	in table
1	CAS Registry Number
1	Cloned(Commentary)
2	Cofactor
2	Natural Substrates/ Products (Substrates)
3	Organism
2	Pathway
2	pH Optimum
5	Protein Variants
1	Purification (Commentary)
1	Reaction
3	Reaction Type
3	Reference
3	Source Tissue
2	Specific Activity [micromol/min/mg]
2	Substrates and Products (Substrate)
1	Systematic Name

Engineering

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Engineering on EC 1.1.1.174 - cyclohexane-1,2-diol dehydrogenase

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Go to Protein Variants Search

L181F

Priestia megaterium

random mutagenesis, A site mutant

739854

L181F/I263N

Priestia megaterium

random mutagenesis, A site mutant

739854

V78I/A82F/A328F/T438I

Priestia megaterium

random mutagenesis, B site mutant

739854

V78I/A82I/A328N

Priestia megaterium

random mutagenesis, B site mutant

739854

additional information

Priestia megaterium

whole-cell-catalyzed multiple regio- and stereoselective functionalizations in cascade reactions enabled by directed evolution: in Escherichia coli, expression of the recombinant enzyme leads to four different mutant whole cells, each leading to one of the three possible stereoisomeric forms of 1,2-cyclohexanediol, namely (R,R)-5, (S,S)-5, (S,R)-5 (meso), or (R,S)-5 (also meso), in a multi-step sequence, overview. Starting from the achiral substrates cyclohexane, cyclohexanol, or cyclohexanone, cyclohexane-1,2-diols as functionalized products are shown to be accessible in three different stereoisomeric forms

739854