1.1.1.176: 12alpha-hydroxysteroid dehydrogenase

This is an abbreviated version!
For detailed information about 12alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

Synonyms

12alpha-HSDH, 12alpha-hydroxy steroid dehydrogenase, CDD59475, dehydrogenase, 12alpha-hydroxy steroid, Elen_2515, NAD+-dependent 12alpha-HSDH, NAD-dependent 12alpha-hydroxysteroid dehydrogenase, NADP+-dependent 12alpha-HSDH, NADP-12alpha-hydroxysteroid dehydrogenase, NADP-dependent 12alpha-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.176 12alpha-hydroxysteroid dehydrogenase

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Results	in table
4	AA Sequence
6	Application
1	CAS Registry Number
4	Cloned(Commentary)
26	Cofactor
3	General Information
1	General Stability
8	Inhibitors
16	kcat/KM [mM/s]
35	KM Value [mM]
9	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
31	Organism
2	Pathway
18	pH Optimum
1	pH Range
5	Protein Variants
11	Purification (Commentary)
1	Reaction
1	Reaction Type
30	Reference
1	Source Tissue
3	Specific Activity [micromol/min/mg]
6	Storage Stability
132	Substrates and Products (Substrate)
22	Subunits
31	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
6	Temperature Stability [°C]
16	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.1.1.176 - 12alpha-hydroxysteroid dehydrogenase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

acetone

Clostridium sp.

-

at 25% v/v and above

668040

Ag+

Clostridium sp.

-

-

347737

Cu2+

Clostridium sp.

-

-

347737

H2

Eggerthella lenta

-

H2 strongly inhibits bile acid oxidation by the enzyme

761221

Hg2+

Clostridium sp.

-

-

347737

p-chloromercuribenzoate

Clostridium sp.

-

-

347737

pyridoxal 5'-phosphate

Clostridium sp.

-

protection by NADP+ or NADPH

347737

additional information

Clostridium sp.

-

no substrate inhibition at high concentration of cholic acid

668040

-