1.1.1.176: 12alpha-hydroxysteroid dehydrogenase
This is an abbreviated version!
For detailed information about 12alpha-hydroxysteroid dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.176
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1.1.1.176
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bile
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synthesis
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clostridium
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sephadex
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7alpha-oh
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7alpha-hydroxysteroid
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unconjugated
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dehydrogenases
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7alpha
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degradation
- 1.1.1.176
- bile
- synthesis
- clostridium
- sephadex
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7alpha-oh
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7alpha-hydroxysteroid
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unconjugated
- dehydrogenases
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7alpha
- degradation
Reaction
Synonyms
12alpha-HSDH, 12alpha-hydroxy steroid dehydrogenase, CDD59475, dehydrogenase, 12alpha-hydroxy steroid, Elen_2515, NAD+-dependent 12alpha-HSDH, NAD-dependent 12alpha-hydroxysteroid dehydrogenase, NADP+-dependent 12alpha-HSDH, NADP-12alpha-hydroxysteroid dehydrogenase, NADP-dependent 12alpha-hydroxysteroid dehydrogenase
ECTree
1.1.1.176 12alpha-hydroxysteroid dehydrogenaseAdvanced search results
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Natural Substrates Products
Natural Substrates Products on EC 1.1.1.176 - 12alpha-hydroxysteroid dehydrogenase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
12-oxolithocholic acid + NADH + H+
deoxycholic acid + NAD+
-
-
-
-
r
cholate + NAD+
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADH + H+
-
-
-
-
?
cholate + NAD+
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADH + H+
-
-
-
-
?
cholate + NADP+
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H+
-
-
-
-
?
cholate + NADP+
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H+
-
-
-
-
?
cholate + NADP+
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H+
-
-
-
-
?
additional information
?
-
-
multistep conversion of cholic acid into ursodeoxycholic acid. Enzyme sources are 7alpha-HSDH from Clostridium absonum (crude extract), 12alpha-HSDH from Clostridium group P, 7beta-HSDH from Clostridium absonum
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-
?
additional information
?
-
-
multistep conversion of cholic acid into ursodeoxycholic acid. Enzyme sources are 7alpha-HSDH from Clostridium absonum (crude extract), 12alpha-HSDH from Clostridium group P, 7beta-HSDH from Clostridium absonum
-
-
?
