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1.1.1.176: 12alpha-hydroxysteroid dehydrogenase

This is an abbreviated version!
For detailed information about 12alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.176

Reaction

cholate
+
NADP+
=
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate
 +
NADPH
 +
H+

Synonyms

12alpha-HSDH, 12alpha-hydroxy steroid dehydrogenase, CDD59475, dehydrogenase, 12alpha-hydroxy steroid, Elen_2515, NAD+-dependent 12alpha-HSDH, NAD-dependent 12alpha-hydroxysteroid dehydrogenase, NADP+-dependent 12alpha-HSDH, NADP-12alpha-hydroxysteroid dehydrogenase, NADP-dependent 12alpha-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.176 12alpha-hydroxysteroid dehydrogenase

Turnover Number

Turnover Number on EC 1.1.1.176 - 12alpha-hydroxysteroid dehydrogenase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6.63
12-oxo-deoxycholic acid
coenzyme: NADPH, pH 7.0, temperature not specified in the publication
-
2.03 - 72.09
12-oxolithocholic acid
10 - 130.62
deoxycholic acid
66.72 - 129.75
NADP+
26.71 - 76.24
NADPH