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1.1.1.179: D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming)

This is an abbreviated version!
For detailed information about D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming), go to the full flat file.

Reaction

D-xylose
+
NADP+
=
D-xylono-1,5-lactone
 +
NADPH
 +
H+

Synonyms

D-xylose (nicotinamide adenine dinucleotide phosphate) dehydrogenase, D-xylose 1-dehydrogenase (NADP), D-xylose dehydrogenase, D-xylose-NADP dehydrogenase, D-xylose:NADP+ oxidoreductase, NADP+-dependent D-xylose dehydrogenase, NADP+:D-xylose dehydrogenase, XDH, xyd1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.179 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming)

Natural Substrates Products

Natural Substrates Products on EC 1.1.1.179 - D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming)

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-xylose + NADP+
D-xylono-1,5-lactone + NADPH + H+
show the reaction diagram
D-xylose + NADP+
D-xylonolactone + NADPH + H+
show the reaction diagram
initial step in xylose degradation
-
-
?
L-arabinose + NADP+
L-arabinono-1,4-lactone + NADPH + H+
show the reaction diagram
-
44% of the activity with D-xylose
-
-
?
additional information
?
-
D-xylose dehydrogenase catalyzes the NADP+-linked oxidation of dihydrodiols of aromatic hydrocarbons to their corresponding catechols and is regarded as a toxication enzyme in the metabolism of carcinogenic polycyclic aromatic hydrocarbons because oxidation by the enzyme yields reactive and redox-active ortho-quinones and reactive oxygen species, broad substrate specificity indicates additional roles of the enzyme in the metabolism of endogenous and xenobiotic carbonyl compounds and the prevention of the development of glycation
-
-
?