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1.1.1.181: cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase

This is an abbreviated version!
For detailed information about cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase, go to the full flat file.

Reaction

cholest-5-ene-3beta,7alpha-diol
+
NAD+
=
7alpha-hydroxycholest-4-en-3-one
+
NADH
+
H+

Synonyms

3beta-hydroxy-DELTA5-C27-steroid oxidoreductase, 5-cholestene-3beta,7alpha-diol 3beta-dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.181 cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase

Engineering

Engineering on EC 1.1.1.181 - cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
molecular analysis of 15 patients with neonatal cholestasis reveals 12 different mutations in HSD3B7 gene, 10 of them leading to complete inactivation of enzyme