1.1.1.19: glucuronate reductase

This is an abbreviated version!
For detailed information about glucuronate reductase, go to the full flat file.

Reaction

Synonyms

AKR1A1, aldehyde reductase, aldehyde reductase II, ALR1, D-glucuronate dehydrogenase, D-glucuronate reductase, D-glucuronic reductase, galacturonate oxidoreductase, hexonate dehydrogenase, L-glucuronate reductase, L-gulonate NAD-3-oxidoreductase, L-hexonate:NADP dehydrogenase, More, NADP-L-gulonate dehydrogenase, PcGOR, TPN l-hexonate dehydrogenase, TPN-L-gulonate dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.19 glucuronate reductase

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Results	in table
245	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
35	Cofactor
46	Disease/ Diagnostics
2	General Stability
67	Inhibitors
11	kcat/KM [mM/s]
53	KM Value [mM]
2	Localization
10	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
25	Organism
8	Pathway
13	pH Optimum
4	pH Range
6	pH Stability
9	Purification (Commentary)
2	Reaction
8	Reaction Type
25	Reference
27	Source Tissue
8	Specific Activity [micromol/min/mg]
2	Storage Stability
72	Substrates and Products (Substrate)
7	Subunits
24	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
4	Temperature Stability [°C]
14	Turnover Number [1/s]

Disease

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Disease on EC 1.1.1.19 - glucuronate reductase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Acute Kidney Injury

Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.

30487609

Anemia

Association between the genetic polymorphisms of the pharmacokinetics of anthracycline drug and myelosuppression in a patient with breast cancer with anthracycline-based chemotherapy.

33774021

Ascorbic Acid Deficiency

A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice.

28060768

Astrocytoma

The role of aldehyde reductase AKR1A1 in the metabolism of gamma-hydroxybutyrate in 1321N1 human astrocytoma cells.

21276435

Astrocytoma

[Effect of AKR1A1 knock-down on H2;O2; and 4-hydroxynonenal-induced cytotoxicity in human 1321N1 astrocytoma cells].

23643085

Breast Neoplasms

Association between the genetic polymorphisms of the pharmacokinetics of anthracycline drug and myelosuppression in a patient with breast cancer with anthracycline-based chemotherapy.

33774021

Carcinoma, Hepatocellular

Metabolism of gamma hydroxybutyrate in human hepatoma HepG2 cells by the aldo-keto reductase AKR1A1.

25256836

Diabetes Mellitus, Type 2

Activities of aldose reductase, ATPases, and nucleotide concentrations of erythrocytes in patients with type 2 (non-insulin-dependent) diabetes mellitus.

1661222

Laryngeal Neoplasms

Increased aldehyde reductase expression mediates acquired radioresistance of laryngeal cancer cells via modulating p53.

22555805

Liver Diseases, Alcoholic

Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members.

10510318

Lymphoma, Non-Hodgkin

Genetic Polymorphisms in Oxidative Stress Pathway Genes and Modification of BMI and Risk of Non-Hodgkin Lymphoma.

22374993

Neoplasms

Quantitative analysis of the human AKR family members in cancer cell lines using the mTRAQ/MRM approach.

23544749

Neoplasms

The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients.

25526449

Osteoporosis

A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice.

28060768

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