Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.1.1.195: cinnamyl-alcohol dehydrogenase

This is an abbreviated version!
For detailed information about cinnamyl-alcohol dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.195

Reaction

cinnamyl alcohol
+
NADP+
=
cinnamaldehyde
 +
NADPH
 +
H+

Synonyms

ADH, AdhA, alcohol dehydrogenase, AtCAD4, BdCAD1, Bmr6, Bradi3g06480, brown midrib6, Brown-midrib 1 protein, CAD, CAD 7/8, CAD1, CAD10, CAD11, CAD12, CAD13, CAD14, CAD15, CAD2, CAD3, CAD4, CAD5, CAD6, CAD7, CAD8, CAD9, CADH I, cinnamyl alcohol dehydrogenase, cinnamyl alcohol dehydrogenase 1, cinnamyl alcohol dehydrogenase 12, cinnamyl alcohol dehydrogenase 2, cinnamyl alcohol dehydrogenase 3, cinnamyl alcohol dehydrogenase 4, cinnamyl alcohol dehydrogenase 5, cinnamyl alcohol dehydrogenase 7, cinnamyl alcohol dehydrogenase 9, cinnamyl alcohol dehydrogenase C, cinnamyl alcohol dehydrogenases, CtCAD1, CtCAD2, CtCAD3, dehydrogenase, cinnamyl alcohol, FC1, FLEXIBLE CULM1, HcCAD1, HcCAD2, LlCAD2, LtuCAD1, More, Mt-CAD1, Mt-CAD2, PhCAD1, PhCAD2, PhCAD3, PhCAD4, PtoCAD1, PtoCAD12, PtoCAD2, PtoCAD3, PtoCAD5, PtoCAD6, PtoCAD7, PtoCAD8, PtoCAD9, ScAdh6p, TaCAD12

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.195 cinnamyl-alcohol dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.195 - cinnamyl-alcohol dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
inhibits 90% at 10 mM
4-coumaryl aldehyde
-
adenosine 2',5'-diphosphate
-
-
adenosine 5'-monophosphate
-
IC50: 1.58 mM with NADP+ and 0.74 mM with NAD+
benzyl alcohol
-
competitive mechanism, substrate inhibition
caffeic acid
-
-
cinnamaldehyde
-
substrate inhibition mediated by cinnamaldehyde concentrations far from the Km value of 0.46 mM, which does not allow for excessively increasing the starting cinnamaldehyde concentration, since the process yield may be greatly affected
cinnamyl alcohol
-
competitive mechanism, substrate inhibition
coniferin
-
with coniferyl alcohol as substrates, noncompetitive inhibition
coniferyl alcohol
-
competitive mechanism, substrate inhibition
coniferyl aldehyde
CTAB
inhibits 92% at 10 mM
diethyldicarbonate
60% inhibition at 1 mM
EDTA
inhibits 92% at 10 mM
Fe3+
-
1 mM, 74% residual activity
ferulic acid
-
-
flavones
Eucalyptus sp.
-
IC50: 0.07-0.055 mM
Hg2+
strong inhibition
iodoacetic acid
-
1 mM, 56% residual activity
Li+
strong inhibition
N-bromosuccimide
-
1 mM, 56% residual activity
Ni
-
CAD activity is not affected by concentrations up to 0.12 mM, phenolic metabolism is not substantially affected by Ni excess
Ni2+
strong inhibition
RNAi
-
RNAi-mediated transient gene silencing in the epidermis leads to a higher penetration efficiency of Blumeria graminis f. sp. tritici (64%) than in the controls. Gene silencing also compromises penetration resistance to varying degrees with different genes against an inappropriate pathogen, Blumeria graminis f. sp. hordei. Co-silencing of CAD and other genes involved in monolignol biosynthesis leads to greater penetration of Blumeria graminis f. sp. tritici or Blumeria graminis f. sp. hordei than when the genes are silenced separately. Gene silencing hamperes host autofluorescence response at fungal contact sites
-
SDS
inhibits 95% at 1%
sinapyl aldehyde
sucrose
10% inhibition at 20%
[[(2-hydroxyphenyl) amino]sulphinyl] acetic acid, 1.1 dimethyl ester
additional information
-