Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.1.1.197: 15-hydroxyprostaglandin dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about 15-hydroxyprostaglandin dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.1.1.197

Reaction

(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate
+
NADP+
=
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate
 +
NADPH
 +
H+

Synonyms

9-ketoprostaglandin reductase, carbonyl reductase, NADP-dependent 15-hydroxyprostaglandin dehydrogenase, NADP-linked 15-hydroxyprostglandin dehydrogenase, NADP-specific 15-hydroxyprostaglandin dehydrogenase, prostaglandin 9-ketoreductase, prostaglandin E 9-ketoreductase, type II 15-hydroxyprostaglandin dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)

Substrates Products

Substrates Products on EC 1.1.1.197 - 15-hydroxyprostaglandin dehydrogenase (NADP+)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-methyl-3-glutathionyl-1,4-benzoquinone + NADPH
? + NADP+
show the reaction diagram
-
toluquinone thioether
-
-
?
2-methyl-3-glutathionyl-1,4-naphthoquinone + NADPH
? + NADP+
show the reaction diagram
-
menadione thioether
-
-
?
4,5-benzo[a]pyrenequinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
5,6-chrysenequinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
7,8-benzo[a]pyrenequinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
acid form of latanoprost + NADP+
? + NADPH
show the reaction diagram
-
-
-
?
glutathione-9-hydroxy-prostaglandin A1 thioether + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
?
glutathione-prostaglandin A1 thioether + NADP+
? + NADPH
show the reaction diagram
-
PGA1-SG, excellent substrate for the placental enzyme
-
-
?
latanoprost + NADP+
? + NADPH
show the reaction diagram
-
-
-
?
menadione + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
prostaglandin A1 + NADP+
15-oxoprostaglandin A1 + NADPH + H+
show the reaction diagram
-
-
-
-
?
prostaglandin B1 + NADP+
15-oxoprostaglandin B1 + NADPH + H+
show the reaction diagram
-
-
-
-
?
prostaglandin E1 + NADP+
15-keto-prostaglandin E1 + NADPH + H+
show the reaction diagram
-
-
-
-
?
prostaglandin E2 + NADP+
15-oxoprostaglandin E2 + NADPH + H+
show the reaction diagram
-
-
-
-
?
prostaglandin E2 + NADPH + H+
prostaglandin F2 + NADP+
show the reaction diagram
prostaglandin E2 + NADPH + H+
prostaglandin F2alpha + NADP+
show the reaction diagram
prostaglandin F + NADP+
? + NADPH
show the reaction diagram
prostaglandin F2alpha + NADP+
prostaglandin E1 + NADPH
show the reaction diagram
prostaglandin I2 + NADP+
? + NADPH
show the reaction diagram
-
poor substrate for the enzyme
-
-
?
thromboxane B2 + NADP+
? + NADPH
show the reaction diagram
-
slowly oxidized
-
-
?
toluquinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
the trans-dihydrodiols trans-dihydroxy-4,5-dihydrobenzo[alpha]pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo[alpha]pyrene, trans-3,4-dihydroxy-3,4-dihydrobenz[alpha]anthracene and its 7-methyl, 12-methyl, and 7,12-dimethyl derivatives are not substrates for the enzyme
-
-
?