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5'-amino-5'-deoxyinosine 5'-N-phosphate + NAD+ + H2O
5'-amino-5'-deoxyxanthosine 5'-N-phosphate + NADH
-
-
-
-
?
5'-mercapto-5'-deoxyinosine 5'-S-phosphate + NAD+ + H2O
5'-mercapto-5'-deoxyxanthosine 5'-phosphate + NADH
-
-
-
-
?
6-thio-IMP + NAD+ + H2O
6-thio-XMP + NADH + H+
-
-
-
-
r
6-thioinosine 5'-phosphate + NAD+ + H2O
6-thioxanthosine 5'-phosphate + NADH
-
-
-
-
?
IMP + APAD+ + H2O
XMP + APADH + H+
IMP + beta-NAD+ + H2O
XMP + beta-NADH + H+
-
-
-
?
IMP + NAD+
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
IMP + thiazole-4-carboxamide adenine dinucleotide + H2O
XMP + reduced thiazole-4-carboxamide adenine dinucleotide + H+
-
-
-
-
r
inosine + NAD+ + H2O
xanthosine + NADH
-
8% of the rate with inosine 5'-phosphate
-
-
?
inosine 5'-diphosphate + NAD+ + H2O
xanthosine 5'-diphosphate + NADH
-
-
-
-
?
inosine 5'-diphosphate + NAD+ + H2O
xanthosine 5'-diphosphate + NADH + H+
inosine 5'-phosphate + 3-acetylpyridine adenine dinucleotide + H2O
xanthosine 5'-phosphate + reduced 3-acetylpyridine adenine dinucleotide
-
-
-
?
inosine 5'-phosphate + acetylpyridine adenine dinucleotide + H2O
xanthosine 5'-phosphate + reduced acetylpyridine adenine dinucleotide
inosine 5'-phosphate + NAD+
xanthosine 5'-phosphate + NADH + H+
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
inosine 5'-phosphorothioate + NAD+ + H2O
xanthosine 5'-phosphorothioate + NADH
-
-
-
-
?
inosine 5'-triphosphate + NAD+ + H2O
xanthosine 5'-triphosphate + NADH
-
-
-
-
?
additional information
?
-
IMP + APAD+ + H2O
XMP + APADH + H+
-
-
-
?
IMP + APAD+ + H2O
XMP + APADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
Q81W29
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
rate-limiting enzyme in the de novo purine biosynthetic pathway leading to the formation of guanine ribonucleotides
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
rate-limiting enzyme in the de novo purine biosynthetic pathway leading to the formation of guanine ribonucleotides
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
r
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
r
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
r
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
?
IMP + NAD+ + H2O
XMP + NADH + H+
-
-
-
-
?
inosine 5'-diphosphate + NAD+ + H2O
xanthosine 5'-diphosphate + NADH + H+
-
-
-
?
inosine 5'-diphosphate + NAD+ + H2O
xanthosine 5'-diphosphate + NADH + H+
Q81W29
-
-
-
?
inosine 5'-diphosphate + NAD+ + H2O
xanthosine 5'-diphosphate + NADH + H+
-
-
-
-
?
inosine 5'-diphosphate + NAD+ + H2O
xanthosine 5'-diphosphate + NADH + H+
-
-
-
?
inosine 5'-diphosphate + NAD+ + H2O
xanthosine 5'-diphosphate + NADH + H+
-
xanthosine 5'-diphosphate is the only product
-
?
inosine 5'-phosphate + acetylpyridine adenine dinucleotide + H2O
xanthosine 5'-phosphate + reduced acetylpyridine adenine dinucleotide
-
-
-
-
?
inosine 5'-phosphate + acetylpyridine adenine dinucleotide + H2O
xanthosine 5'-phosphate + reduced acetylpyridine adenine dinucleotide
-
-
-
-
?
inosine 5'-phosphate + NAD+
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
subdomain of the enzyme is not required for catalytic activity
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
r
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
r
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
the enzyme is important for the synthesis of guanine nucleotides
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
ir
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
rate-limiting step of the de novo guanine nucleotide biosynthesis
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
347905, 347912, 347918, 347931, 667473, 667935, 667965, 667976, 667980, 670881, 684706, 689355, 706815, 706817 -
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
ir
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
r
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
rate-limiting step of the de novo guanine nucleotide biosynthesis
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
rate-limiting step of the de novo guanine nucleotide biosynthesis
-
-
ir
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
the enzyme performs the rate-limiting step in guanine nucleotide biosynthesis
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
ir
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
obligatory step in biosynthesis of nucleic acid guanine
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
enzyme is highly specific for both inosine 5'-phosphate and NAD+
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
ir
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
Parainfluenza virus
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
Parainfluenza virus
-
rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
enzyme linked to proliferation and malignancy
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
rate-limiting step of the de novo guanine nucleotide biosynthesis
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
ir
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
the reaction is irreversible over the range of pH 5.5 to pH 8.8, step in guanylic acid biosynthesis
-
-
ir
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
the reaction is irreversible over the range of pH 5.5 to pH 8.8
-
-
ir
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
r
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
rate-limiting step of the de novo guanine nucleotide biosynthesis
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
-
IMP oxidation is the predominant metabolic route leading to ureide synthesis
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
IMPDH catalyzes a dehydrogenase reaction and a hydrolysis reaction, a redox step producing NADH and the covalent intermediate E-xanthosine 5'-monophosphate and a hydrolysis step that produces xanthosine 5'-monophosphate. The enzyme toggles between the open conformation required for the dehydrogenase reaction and the closed conformation of the hydrolase reaction by moving a mobile flap into the NAD site. The dehydrogenase and hydrolase reactions display significant differences in the host (Homo sapiens) and parasite (Cryptosporidium parvum) enzymes, in keeping with the phylogenetic and structural divergence of their active sites
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
IMPDH catalyzes a dehydrogenase reaction and a hydrolysis reaction, a redox step producing NADH and the covalent intermediate E-xanthosine 5'-monophosphate* and a hydrolysis step that produces xanthosine 5'-monophosphate. The enzyme toggles between the open conformation required for the dehydrogenase reaction and the closed conformation of the hydrolase reaction by moving a mobile flap into the NAD site. The dehydrogenase and hydrolase reactions display significant differences in the host (Homo sapiens) and parasite (Cryptosporidium parvum) enzymes, in keeping with the phylogenetic and structural divergence of their active sites
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
additional information
?
-
-
IMP-enzyme binding structure analysis, overview
-
-
?
additional information
?
-
the enzyme does not hydrolyze oxanosine monophosphate
-
-
-
additional information
?
-
-
IMP-enzyme binding structure analysis, overview
-
-
?
additional information
?
-
the enzyme does not hydrolyze oxanosine monophosphate
-
-
-
additional information
?
-
-
IMP-enzyme binding structure analysis, overview
-
-
?
additional information
?
-
-
the enzyme does not hydrolyze oxanosine monophosphate
-
-
-
additional information
?
-
-
the enzyme binds both RNA and DNA in vitro and in vivo
-
-
?
additional information
?
-
-
the CBS subdomain of IMPDH coordinately regulates the adenine and guanine nucleotide pool
-
-
?
additional information
?
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enzyme inhibition by mycophenolic acid impairs maturation and function of dendritic cells due to low GTP levels and reduced expression of CD80, CD40, CD86, CD54, and CD83 in dendritic cells, accompanied by a decreased capacity to stimulate T-lymphocytes
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enzyme mutations are involved in autosomal dominant retinitis pigmentosa, pathological mechanism, overview
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increased activities of IMP DH and GMP synthase and in the elevated concentrations of guanylates in hepatomas and other tumor cells
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inhibition of the enzyme in K562 cells sensitizes the before resistant cells to methotrexate
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isozyme IMPDH-1 is essential for T lymphocyte development, enzyme inhibitor mycophenolic acid inhibits tumor-associated angiogenesis
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the enzyme is rate-limiting in the de novo synthesis of guanine nucleotides
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ssDNA and RNA binding of wild-type and mutant IMPDH1s
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the enzyme binds both RNA and DNA in vitro and in vivo
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the enzyme interacts with GTP which leads to formation of linear arrays, GTP reverses the enzyme aggregation by inhibitor mycophenolic acid
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assay method optimization. XMP detection and quantification by anion exchange chromatography
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assay method optimization. XMP detection and quantification by anion exchange chromatography
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additional information
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assay method optimization. XMP detection and quantification by anion exchange chromatography
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additional information
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the enzyme does not hydrolyze oxanosine monophosphate
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additional information
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increased activities of IMP DH and GMP synthase and in the elevated concentrations of guanylates in hepatomas and other tumor cells
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additional information
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the parasite damages fetuses in utero and threatens immunocompromized individuals
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additional information
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the parasite damages fetuses in utero and threatens immunocompromized individuals
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additional information
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the enzyme does not hydrolyze oxanosine monophosphate
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additional information
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the enzyme binds both RNA and DNA in vitro and in vivo
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additional information
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IMP- and XMP-enzyme binding structure analysis, overview
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