1.1.1.206: tropinone reductase I
This is an abbreviated version!
For detailed information about tropinone reductase I, go to the full flat file.
Word Map on EC 1.1.1.206
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1.1.1.206
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tropane
-
reductases
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hyoscyamine
-
scopolamine
-
datura
-
pseudotropine
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stramonium
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solanaceae
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calystegines
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putrescine
-
n-methyltransferase
-
solanaceous
-
3-quinuclidinone
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synthesis
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nortropane
- 1.1.1.206
-
tropane
- reductases
- hyoscyamine
- scopolamine
- datura
- pseudotropine
- stramonium
- solanaceae
-
calystegines
- putrescine
- n-methyltransferase
-
solanaceous
- 3-quinuclidinone
- synthesis
-
nortropane
Reaction
Synonyms
BaTRI, dehydrogenase, tropine, DnTR1, DsTRI, EC 1.1.1.293, More, TR-I, TR1, TRI, Tri2, tropine biosynthetic tropinone reductase, Tropine dehydrogenase, tropine-forming reductase, tropine-forming tropinone reductase, tropinone reductase, tropinone reductase I, tropinone reductase II, tropinone reductase-I, tropinone reductase-I 2, WcTR-I, WsTR-I, WsTR-I protein
ECTree
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Systematic Name
Systematic Name on EC 1.1.1.206 - tropinone reductase I
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tropine:NADP+ 3alpha-oxidoreductase
Also oxidizes other tropan-3alpha-ols, but not the corresponding beta-derivatives [1]. This enzyme along with EC 1.1.1.236, tropinone reductase II, represents a branch point in tropane alkaloid metabolism [4]. Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines [4]. Both enzymes are always found together in any given tropane-alkaloid-producing species, have a common substrate, tropinone, and are strictly stereospecific [3].