1.1.1.211: long-chain-3-hydroxyacyl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about long-chain-3-hydroxyacyl-CoA dehydrogenase, go to the full flat file.

Reaction

Synonyms

2-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-oxoacyl-CoA thiolase, 3-hydroxyacyl-CoA dehydrogenase, beta-hydroxyacyl-CoA dehydrogenase, enoyl-coenzyme A (CoA) hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase trifunctional protein, HADHA, LCHAD, LHCAD, long chain 3-hydroxyacyl-CoA dehydrogenase, long chain fatty acid oxidase, long-chain 3-hydroxy acyl-CoA dehydrogenase, long-chain 3-hydroxy-acyl-CoA dehydrogenase, long-chain 3-hydroxyacyl coenzyme A dehydrogenase, long-chain 3-hydroxyacyl-CoA dehydrogenase, long-chain L-3 hydroxyacyl-CoA dehydrogenase, mitochondrial trifunctional protein, More, MTP

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase

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Results	in table
2	Activating Compound
32	AA Sequence
6	Application
1	CAS Registry Number
3	Cloned(Commentary)
17	Cofactor
1482	Disease/ Diagnostics
4	Expression
22	General Information
2	Inhibitors
2	KM Value [mM]
14	Localization
7	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
46	Organism
6	Pathway
12	PDB ID
2	pH Optimum
8	Protein Variants
3	Purification (Commentary)
1	Reaction
3	Reaction Type
34	Reference
54	Source Tissue
10	Specific Activity [micromol/min/mg]
34	Substrates and Products (Substrate)
4	Subunits
52	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 1.1.1.211 - long-chain-3-hydroxyacyl-CoA dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase

This enzyme was purified from the mitochondrial inner membrane. The enzyme has a preference for long-chain substrates, and activity with a C16 substrate was 6- to 15-fold higher than with a C4 substrate (cf. EC 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase).