1.1.1.224: mannose-6-phosphate 6-reductase

This is an abbreviated version!
For detailed information about mannose-6-phosphate 6-reductase, go to the full flat file.

Reaction

Synonyms

6-phosphomannose reductase, CaM6PR, M6PR, mannose 6 phosphate reductase, mannose 6-phosphate reductase, mannose-6-phosphate reductase, NADP-dependent mannose-6-P:mannitol-1-P oxidoreductase, NADPH-dependent M6P reductase, NADPH-dependent mannose 6-phosphate reductase, NADPH-mannose-6-P reductase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.224 mannose-6-phosphate 6-reductase

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Results	in table
6	AA Sequence
2	Application
1	CAS Registry Number
8	Cloned(Commentary)
14	Cofactor
1	Expression
2	General Stability
3	Inhibitors
10	KM Value [mM]
8	Localization
8	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
22	Organism
1	Oxidation Stability
1	Pathway
4	pH Optimum
1	pH Range
3	pH Stability
2	Protein Variants
6	Purification (Commentary)
1	Reaction
3	Reaction Type
17	Reference
23	Source Tissue
10	Specific Activity [micromol/min/mg]
2	Storage Stability
16	Substrates and Products (Substrate)
5	Subunits
17	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]

Inhibitors

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Inhibitors on EC 1.1.1.224 - mannose-6-phosphate 6-reductase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

NaCl

Apium graveolens

-

47% reduction by 100 mM

348002

siRNA

Phelipanche aegyptiaca

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transformed tomato plants containing siRNA from the M6PR of Orobanche aegyptiaca show normal growth and development, accumulation of M6PR siRNA in transgenic tomatoes correlates with decreased levels of M6PR mRNA. Amount of endogenous M6PR mRNA in the tubercles and underground shoots of Orobanche aegyptiaca grown on transgenic host plants is reduced by 60%-80%. Concomitant with M6PR mRNA suppression, there is a significant decrease in mannitol level and a significant increase in the percentage of dead Orobanche aegyptiaca tubercles on the transgenic host plants. Detection of mir390, which is involved with cytoplasmic dsRNA processing, indicates to the existence of gene-silencing mechanisms in Orobanche spp. Gene silencing mechanisms are probably involved with the production of decreased levels of M6PR mRNA in the parasites grown on the transformed tomato lines

700701

-

additional information

Phelipanche ramosa

-

overview over substrate and product analogues

348007

-