1.1.1.23: histidinol dehydrogenase
This is an abbreviated version!
For detailed information about histidinol dehydrogenase, go to the full flat file.
Reaction
Synonyms
11412251, BN980_GECA03s06082g, BsHDH, GcHDH, HDH, HIS4 protein, HisD, histidinol dehydrogenase, HLDase, L-histidinol dehydrogenase
ECTree
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Cofactor
Cofactor on EC 1.1.1.23 - histidinol dehydrogenase
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NAD+
amino acid residues contributing to NAD+ binding include Tyr129, Gly132, and Asn221 for phosphate binding, Gln193 and Asn221 for adenosine sugar binding, and Phe58, Gln193, and Tyr223 for adenine base binding
NAD+
the amine group is responsible of the substrate orientation by interacting with the Zn2+ while the overall stabilization of the cation changed between the unbound and bound forms
NAD+
the amine group is responsible of the substrate orientation by interacting with the Zn2+ while the overall stabilization of the cation changes between the unbound and bound forms