1.1.1.244: methanol dehydrogenase
This is an abbreviated version!
For detailed information about methanol dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.244
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1.1.1.244
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methylobacterium
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formaldehyde
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quinone
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methane
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methanotrophs
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pqq
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extorquens
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quinoproteins
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denitrificans
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methylotrophy
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methylamine
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paracoccus
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lanthanide
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methylophilus
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hyphomicrobium
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methanolicus
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methylomonas
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methylosinus
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methylococcus
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methane-oxidizing
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methanol-grown
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trichosporium
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lanthanide-dependent
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pqq-dependent
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methylomicrobium
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pink-pigmented
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pyrrolo-quinoline
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rump
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methylocystis
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methylophaga
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methylobacter
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xoxf-type
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pqq-containing
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organophilum
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phyllosphere
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quinone-dependent
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methylacidiphilum
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rare-earth
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ch3oh
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dye-linked
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biotechnology
- 1.1.1.244
- methylobacterium
- formaldehyde
- quinone
- methane
- methanotrophs
- pqq
- extorquens
-
quinoproteins
- denitrificans
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methylotrophy
- methylamine
-
paracoccus
-
lanthanide
- methylophilus
- hyphomicrobium
- methanolicus
- methylomonas
- methylosinus
- methylococcus
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methane-oxidizing
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methanol-grown
- trichosporium
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lanthanide-dependent
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pqq-dependent
- methylomicrobium
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pink-pigmented
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pyrrolo-quinoline
-
rump
- methylocystis
- methylophaga
- methylobacter
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xoxf-type
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pqq-containing
- organophilum
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phyllosphere
-
quinone-dependent
- methylacidiphilum
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rare-earth
- ch3oh
-
dye-linked
- biotechnology
Reaction
Synonyms
activator-independent methanol dehydrogenase, ADH, BFZC1_05383, BsMdh, Bsph_4187, CNE_2c13570, dehydrogenase, methanol, group III NAD-dependent alcohol dehydrogenase, lxmdh, MDH, Mdh1, MDH2, Mdh3, MEDH, methanol dehydrogenase 2, More, NAD+ dependent methanol dehydrogenase, NAD-dependent MDH, NAD-dependent methanol dehydrogenase, XoxF
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.244 - methanol dehydrogenase
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REACTION DIAGRAM
formaldehyde + NADH + H+
methanol + NAD+
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Mdhs generally show higher activity and affinity for formaldehyde compared to methanol
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-
r
formaldehyde + NADH + H+
methanol + NAD+
key step for both toxic formaldehyde elimination
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-
r
formaldehyde + NADH + H+
methanol + NAD+
key step for both toxic formaldehyde elimination
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-
r
formaldehyde + NADH + H+
methanol + NAD+
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Mdhs generally show higher activity and affinity for formaldehyde compared to methanol
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-
r
formaldehyde + NADH + H+
methanol + NAD+
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Mdhs generally show higher activity and affinity for formaldehyde compared to methanol
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-
r
methanol + NAD+
formaldehyde + NADH + H+
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-
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r
methanol + NAD+
formaldehyde + NADH + H+
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33% of activity with ethanol
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r
methanol + NAD+
formaldehyde + NADH + H+
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44% of activity with ethanol, NADP+ cannot replace NAD+
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?
methanol + NAD+
formaldehyde + NADH + H+
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no activity with 2-propanol, 2,3-butandiol, mannitol and glycerol
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?
methanol + NAD+
formaldehyde + NADH + H+
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involved in initial methanol oxidation
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r
methanol + NAD+
formaldehyde + NADH + H+
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involved in initial methanol oxidation
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r
methanol + NAD+
formaldehyde + NADH + H+
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involved in initial methanol oxidation
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r
methanol + NAD+
formaldehyde + NADH + H+
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involved in initial methanol oxidation
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r
methanol + NAD+
formaldehyde + NADH + H+
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very low activity, Mdhs generally show higher activity and affinity for formaldehyde compared to methanol
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r
methanol + NAD+
formaldehyde + NADH + H+
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very low activity. Mdhs generally show higher activity and affinity for formaldehyde compared to methanol
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-
r
methanol + NAD+
formaldehyde + NADH + H+
in nature, methanol dehydrogenase (Mdh), which converts methanol to formaldehyde, highly favors the reverse reaction
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-
r
methanol + NAD+
formaldehyde + NADH + H+
key step for ethanol production in bacterial methylotrophy
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r
methanol + NAD+
formaldehyde + NADH + H+
key step for ethanol production in bacterial methylotrophy
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r
methanol + NAD+
formaldehyde + NADH + H+
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very low activity, Mdhs generally show higher activity and affinity for formaldehyde compared to methanol
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-
r
methanol + NAD+
formaldehyde + NADH + H+
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very low activity. Mdhs generally show higher activity and affinity for formaldehyde compared to methanol
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-
r
methanol + NAD+
formaldehyde + NADH + H+
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-
-
r
methanol + NAD+
formaldehyde + NADH + H+
in nature, methanol dehydrogenase (Mdh), which converts methanol to formaldehyde, highly favors the reverse reaction
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-
r
methanol + NAD+
formaldehyde + NADH + H+
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very low activity, Mdhs generally show higher activity and affinity for formaldehyde compared to methanol
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-
r
methanol + NAD+
formaldehyde + NADH + H+
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very low activity. Mdhs generally show higher activity and affinity for formaldehyde compared to methanol
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-
r
methanol + NAD+
formaldehyde + NADH + H+
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-
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r
methanol + NAD+
formaldehyde + NADH + H+
XoxF may not be involved in methylotrophy
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-
?
formaldehyde + NADPH + H+
I3DTM5, I3E2P9
Mdh enzyme mutant D41G, no activity of the wild-type enzyme with NADP(H)
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r
methanol + NADP+
formaldehyde + NADPH + H+
I3DTM5, I3E2P9
Mdh enzyme mutant D98G, no activity of the wild-type enzyme with NADP(H)
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-
r
methanol + NADP+
formaldehyde + NADPH + H+
I3DTM5, I3E2P9
Mdh enzyme mutant D98G, no activity of the wild-type enzyme with NADP(H)
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-
r
methanol + NADP+
formaldehyde + NADPH + H+
I3DTM5, I3E2P9
Mdh enzyme mutant D41G, no activity of the wild-type enzyme with NADP(H)
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-
r
n-butanal + NADH
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87% of activity with ethanol
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?
n-butanol + NAD+
n-butanal + NADH
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87% of activity with ethanol
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r
n-propanal + NADH
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71% of activity with ethanol
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?
n-propanol + NAD+
n-propanal + NADH
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71% of activity with ethanol
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r
?
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all Mdh isozymes catalyze the oxidation of methanol, but the catalytic activity for methanol is considerably lower than for most other alcohols tested. The isozymes exhibit a broad and different substrate specificity range, and display both dehydrogenase and reductase activities. Isozyme Mdh3 shows the highest activity of all isozymes
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-
?
additional information
?
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efficient coupling with the irreversible sequestration of formaldehyde by 3-hexulose-6-phosphate synthase (Hps) and 6-phospho-3-hexuloseisomerase (Phi) serves as the key driving force to pull the pathway equilibrium toward central metabolism
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-
?
additional information
?
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I3DTM5
poor activity with 2-propanol and 1,2-popanediol
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-
?
additional information
?
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poor activity with 2-propanol and 1,2-popanediol
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?
additional information
?
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poor activity with 2-propanol and 1,2-popanediol
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-
?
additional information
?
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all Mdh isozymes catalyze the oxidation of methanol, but the catalytic activity for methanol is considerably lower than for most other alcohols tested. The isozymes exhibit a broad and different substrate specificity range, and display both dehydrogenase and reductase activities. Isozyme Mdh3 shows the highest activity of all isozymes
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-
?
additional information
?
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I3DTM5
poor activity with 2-propanol and 1,2-popanediol
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-
?
additional information
?
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poor activity with 2-propanol and 1,2-popanediol
-
-
?
additional information
?
-
efficient coupling with the irreversible sequestration of formaldehyde by 3-hexulose-6-phosphate synthase (Hps) and 6-phospho-3-hexuloseisomerase (Phi) serves as the key driving force to pull the pathway equilibrium toward central metabolism
-
-
?
additional information
?
-
-
all Mdh isozymes catalyze the oxidation of methanol, but the catalytic activity for methanol is considerably lower than for most other alcohols tested. The isozymes exhibit a broad and different substrate specificity range, and display both dehydrogenase and reductase activities. Isozyme Mdh3 shows the highest activity of all isozymes
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-
?