1.1.1.248: salutaridine reductase (NADPH)

This is an abbreviated version!
For detailed information about salutaridine reductase (NADPH), go to the full flat file.

Word Map on EC 1.1.1.248

Reaction

salutaridinol
+
NADP+
=
salutaridine
+
NADPH
+
H+

Synonyms

More, PsSAR, reductase, salutaridine 7-, SalR, salutaridine 7-reductase, salutaridine reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.248 salutaridine reductase (NADPH)

Application

Application on EC 1.1.1.248 - salutaridine reductase (NADPH)

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis
KP400665
the Papaper somniferum enzymes salutaridine synthase (SAS), salutaridine reductase (SAR) and salutaridinol acetyltransferase (SAT) are functionally co-expressed in Saccharomyces cerevisiae and optimization of the pH conditions allows for productive spontaneous rearrangement of salutaridinol-7-O-acetate and synthesis of thebaine from (R)-reticuline. Upon reconstitution of a 7-gene pathway for the production of codeine and morphine from (R)-reticuline, activity of salutaridine reductase and codeine-O-demethylase likely limit flux to morphine synthesis