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1.1.1.269: 2-(S)-hydroxypropyl-CoM dehydrogenase

This is an abbreviated version!
For detailed information about 2-(S)-hydroxypropyl-CoM dehydrogenase, go to the full flat file.

Wordmap for 1.1.1.269

Word Map on EC 1.1.1.269 Wordmap for 1.1.1.269

Reaction

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(2S)-2-hydroxypropyl-CoM
+
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NAD+
=
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2-oxopropyl-CoM
+
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NADH
+
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H+

Synonyms

(S)-hydroxypropyl-coenzyme M dehydrogenase, (S)-hydroxypropylthioethanesulfonate dehydrogenase, 2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase, HPCDH3, S-HPCDH, xecE, xecE1, xecE3

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                EC 1.1.1.2691.1.1.269 2-(S)-hydroxypropyl-CoM dehydrogenase

Engineering

Engineering on EC 1.1.1.269 - 2-(S)-hydroxypropyl-CoM dehydrogenase

for references in articles please use BRENDA:EC1.1.1.269

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K214A
substantially reduced catalytic efficiencies with the natural substrates in both the oxidative and reductive direction
R211A
substantially reduced catalytic efficiencies with the natural substrates in both the oxidative and reductive direction
S143A
residue acts as H-bond donor to substrate and in charge stabilization of the transition state, large increase in Km value
Y156A
mutation in general acid/base, large increase in Km value