1.1.1.27: L-lactate dehydrogenase

This is an abbreviated version!
For detailed information about L-lactate dehydrogenase, go to the full flat file.

Reaction

Synonyms

A4-LDH, AdhE, alpha-HBDH, alpha-hydroxybutyrate dehydrogenase, anaerobic lactate dehydrogenase, BbLDH, dehydrogenase, lactate, eLDHA, eLDHB, Epsilon crystallin, epsilon-crystallin, H4-L-lactate dehydrogenase, HBDH, heart LDH, Immunogenic protein p36, L(+)-nLDH, L-(+)-lactate dehydrogenase, L-lactate dehydrogenase, L-lactate dehydrogenase B, L-lactic acid dehydrogenase, L-lactic dehydrogenase, L-LDH, L-Ldh0845, L-nLDH, lactate dehydrogenase, lactate dehydrogenase 5, lactate dehydrogenase A, lactate dehydrogenase B, lactate dehydrogenase NAD-dependent, lactic acid dehydrogenase, lactic dehydrogenase, LctD, LDH, LDH-1, LDH-2, LDH-3, LDH-4, LDH-5, LDH-A, LDH-A4, LDH-m4, LDH1, LDH2, LdhA, LDHB, ldhL, LDHL1, LDHL2, LOX, LutACB, mL-LDH, mLDH, More, muscle LDH, NAD-dependent lactate dehydrogenase, NAD-lactate dehydrogenase, NGO0904, NGO0905, NGO0906, nitric oxideinducible l-lactate dehydrogenase, PfLDH, proteins, specific or class, anoxic stress response, p34, Sa-LDH-1, SMU.1115, SMU_1115, TeLdhL, Tsac_0416

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.27 L-lactate dehydrogenase

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Results	in table
100	Activating Compound
17043	AA Sequence
52	Application
1	CAS Registry Number
61	Cloned(Commentary)
268	Cofactor
18	Crystallization (Commentary)
31225	Disease/ Diagnostics
8	Expression
51	General Information
12	General Stability
95	IC50 Value
441	Inhibitors
34	kcat/KM [mM/s]
82	Ki Value [mM]
326	KM Value [mM]
25	Localization
29	Metals/Ions
44	Molecular Weight [Da]
95	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
304	Organism
17	Pathway
673	PDB ID
90	pH Optimum
27	pH Range
9	pH Stability
9	pI Value
4	Posttranslational Modification
43	Protein Variants
76	Purification (Commentary)
7	Reaction
3	Reaction Type
287	Reference
1	Renatured (Commentary)
176	Source Tissue
89	Specific Activity [micromol/min/mg]
8	Storage Stability
431	Substrates and Products (Substrate)
63	Subunits
242	Synonyms
1	Systematic Name
36	Temperature Optimum [°C]
5	Temperature Range [°C]
57	Temperature Stability [°C]
99	Turnover Number [1/s]

pH Stability

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pH Stability on EC 1.1.1.27 - L-lactate dehydrogenase

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3.8 - 7

Oryctolagus cuniculus

-

1 h, 25°C, pH 3.8: 50% loss of activity, pH 7.0: stable, mutant enzyme with a deletion of 10 N-terminal amino acids

654791

4 - 8

Lactobacillus sp.

-

rather stable from pH 4.0 to pH 8.0, but rapid decline in activity below pH 4.0 and above pH 8.0

687249

5 - 7.5

Lactococcus lactis

-

rapid loss of activity below pH 5.0 and above pH 7.5

286436

5.5 - 7

Oryctolagus cuniculus

-

1 h, 25°C, pH 5.5: 50% loss of activity, pH 7.0: stable, wilde-type enzyme

654791

5.7 - 7

Oryctolagus cuniculus

-

1 h, 25°C, pH 5.7: 50% loss of activity, pH 7.0: stable, mutant enzyme with a deletion of 5 N-terminal amino acids

654791

5.8 - 8.2

Thermoanaerobacter ethanolicus

B1A4R6

purified recombinant enzyme, 1-5 h, 70°C, completely stable

711181

6

Limosilactobacillus fermentum

A0A2K9Y5T7

stable

762306

6.5

Staphylococcus epidermidis

-

highest stability at

286435

additional information

Thermoanaerobacter ethanolicus

B1A4R6

incubation of TeLdhL at lower pH results in a rapid inactivation of the enzyme

711181