1.1.1.283: methylglyoxal reductase (NADPH)

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For detailed information about methylglyoxal reductase (NADPH), go to the full flat file.

Reaction

Synonyms

AKR, aldo-keto reductase, AlrA, CaGre2, CANTEDRAFT_112488, D-lactaldehyde dehydrogenase, EC 1.1.1.78, Gre2, GRE2 gene product, GRE2/YOL151W, Gre2p, GRE3, GRP2, Lbuc_0522, MeGR, Mer, methylglyoxal reductase, methylglyoxal reductase (NADPH dependent), methylglyoxal/isovaleraldehyde reductase, MG reductase, MG-specific aldolase reductase, MGR, More, NADPH-dependent methylglyoxal reductase, NADPH-linked aldolase reductase, PAS_chr3_0744, SakR1, YGL039w1, YGL039w2, YOL151W, YOL151w gene product

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.283 methylglyoxal reductase (NADPH)

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Results	in table
10	Activating Compound
316	AA Sequence
1	Application
1	CAS Registry Number
13	Cloned(Commentary)
30	Cofactor
4	Crystallization (Commentary)
112	General Information
28	Inhibitors
2	kcat/KM [mM/s]
29	KM Value [mM]
27	Localization
1	Metals/Ions
8	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
59	Organism
7	Pathway
6	PDB ID
5	pH Optimum
1	pH Stability
1	Posttranslational Modification
4	Protein Variants
5	Purification (Commentary)
5	Reaction
51	Reference
1	Source Tissue
39	Specific Activity [micromol/min/mg]
2	Storage Stability
103	Substrates and Products (Substrate)
5	Subunits
128	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
3	Temperature Stability [°C]
17	Turnover Number [1/s]

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Application on EC 1.1.1.283 - methylglyoxal reductase (NADPH)

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

synthesis

Saccharomyces cerevisiae

Q12068

engineeering of Sacharomyces cerevisiae for specific reduction of a variety of carbonyl compounds by altering the levels of fatty acid synthase Fas, aldo-keto reductase Ypr1 and R-acetoxy ketone reductase Gre2. By choosing the appropriate engineered yeast strain, it is possible to prepare many of the alcohols in high stereochemical purities and good chemical yields. For example, in the reductions of some alpha-unsubstituted beta-keto esters, genetically disabling Fas virtually eliminates production of (3R)-alcohols. Overexpressing (3S)-selective reductase Gre2 in the Fas knockout strain gives yeast cells that reduce these ketones to the corresponding (3S)-alcohols in >98% ee in each case

738443