1.1.1.286: isocitrate-homoisocitrate dehydrogenase

This is an abbreviated version!
For detailed information about isocitrate-homoisocitrate dehydrogenase, go to the full flat file.

Reaction

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
+
NAD+
=
2-oxoadipate
+
CO2
+
NADH
+
H+

Synonyms

3-carboxy-2-hydroxyadipate dehydrogenase, HICDH, homoisocitrate dehydrogenase, isocitrate-homoisocitrate dehydrogenase, More, Saci_2375, TK0280

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.286 isocitrate-homoisocitrate dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.286 - isocitrate-homoisocitrate dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2S,3S)-thiahomoisocitrate
-
3-carboxypropylidenemalate
homoisocitrate
-
competitive, pH-dependent substrate inhibition
isocitrate
-
competitive, pH-dependent substrate inhibition
K+
-
absolute requirement, inhibitory above 0.4 M
Mn2+
-
inhibitory above 1 mM
NADH
-
product inhibitor
NH4+
-
may substitute for K+, inhibitory above 0.2 M
potassium acetate
-
-