1.1.1.286: isocitrate-homoisocitrate dehydrogenase

This is an abbreviated version!
For detailed information about isocitrate-homoisocitrate dehydrogenase, go to the full flat file.

Reaction

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
+
NAD+
=
2-oxoadipate
+
CO2
+
NADH
+
H+

Synonyms

3-carboxy-2-hydroxyadipate dehydrogenase, HICDH, homoisocitrate dehydrogenase, isocitrate-homoisocitrate dehydrogenase, More, Saci_2375, TK0280

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.286 isocitrate-homoisocitrate dehydrogenase

Reference

Reference on EC 1.1.1.286 - isocitrate-homoisocitrate dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Miyazaki, J.; Kobashi, N.; Nishiyama, M.; Yamane, H.
Characterization of homoisocitrate dehydrogenase involved in lysine biosynthesis of an extremely thermophilic bacterium, Thermus thermophilus HB27, and evolutionary implication of beta-decarboxylating dehydrogenase
J. Biol. Chem.
278
1864-1871
2003
Thermus thermophilus (Q72IW9), Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039 (Q72IW9)
Manually annotated by BRENDA team
Miyazaki, K.
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase
Biochem. Biophys. Res. Commun.
331
341-346
2005
Pyrococcus horikoshii
Manually annotated by BRENDA team
Miyazaki, K.
Identification of a novel trifunctional homoisocitrate dehydrogenase and modulation of the broad substrate specificity through site-directed mutagenesis
Biochem. Biophys. Res. Commun.
336
596-602
2005
Deinococcus radiodurans
Manually annotated by BRENDA team
Lin, Y.; Volkman, J.; Nicholas, K.M.; Yamamoto, T.; Eguchi, T.; Nimmo, S.L.; West, A.H.; Cook, P.F.
Chemical mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae
Biochemistry
47
4169-4180
2008
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Lin, Y.; West, A.H.; Cook, P.F.
Potassium is an activator of homoisocitrate dehydrogenase from Saccharomyces cerevisiae
Biochemistry
47
10809-10815
2008
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Takahashi, K.; Nakanishi, F.; Tomita, T.; Akiyama, N.; Lassak, K.; Albers, S.V.; Kuzuyama, T.; Nishiyama, M.
Characterization of two ?-decarboxylating dehydrogenases from Sulfolobus acidocaldarius
Extremophiles
20
843-853
2016
Sulfolobus acidocaldarius (Q4J6C9), Sulfolobus acidocaldarius, Sulfolobus acidocaldarius MW001 (Q4J6C9)
Manually annotated by BRENDA team
Takahashi, K.; Tomita, T.; Kuzuyama, T.; Nishiyama, M.
Determinants of dual substrate specificity revealed by the crystal structure of homoisocitrate dehydrogenase from Thermus thermophilus in complex with homoisocitrate-Mg(2+)-NADH
Biochem. Biophys. Res. Commun.
478
1688-1693
2016
Thermus thermophilus (Q72IW9), Thermus thermophilus DSM 7039 (Q72IW9)
Manually annotated by BRENDA team
Shimizu, T.; Yin, L.; Yoshida, A.; Yokooji, Y.; Hachisuka, S.I.; Sato, T.; Tomita, T.; Nishida, H.; Atomi, H.; Kuzuyama, T.; Nishiyama, M.
Structure and function of an ancestral-type beta-decarboxylating dehydrogenase from Thermococcus kodakarensis
Biochem. J.
474
105-122
2017
Thermococcus kodakarensis (Q5JFV8), Thermococcus kodakarensis KRD1 (Q5JFV8)
Manually annotated by BRENDA team