1.1.1.299: malate dehydrogenase [NAD(P)+]

This is an abbreviated version!
For detailed information about malate dehydrogenase [NAD(P)+], go to the full flat file.

Reaction

Synonyms

LDH-like MalDH, MDH II, NAD(P)-dependent malate dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.299 malate dehydrogenase [NAD(P)+]

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Results

in table

6

AA Sequence

1

CAS Registry Number

1

Cloned(Commentary)

10

Cofactor

1

Crystallization (Commentary)

8

Inhibitors

3

KCat/KM [mM/s]

1

Ki Value [mM]

15

KM Value [mM]

6

Molecular Weight [Da]

2

Natural Substrates/ Products (Substrates)

4

Organism

2

Pathway

2

pH Optimum

2

pH Range

1

pH Stability

2

Purification (Commentary)

3

Reaction

4

Reference

5

Specific Activity [micromol/min/mg]

16

Substrates and Products (Substrate)

4

Subunits

3

Synonyms

1

Systematic Name

1

Temperature Optimum [°C]

1

Temperature Range [°C]

2

Temperature Stability [°C]

10

Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.1.1.299 - malate dehydrogenase [NAD(P)+]

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SYSTEMATIC NAME

IUBMB Comments

(S)-malate:NAD(P)+ oxidoreductase

This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyses only the reduction of oxaloacetate, and can use NAD+ and NADP+ with similar specific activity [1]. Different from EC 1.1.1.37 (malate dehydrogenase (NAD+)), EC 1.1.1.82 (malate dehydrogenase (NADP+)) and EC 1.1.5.4 (malate dehydrogenase (quinone)).