1.1.1.3: homoserine dehydrogenase

This is an abbreviated version!
For detailed information about homoserine dehydrogenase, go to the full flat file.

Reaction

Synonyms

AK-HDH, AK-HSD-1, AK-HSDH, AK-HseDH, aspartate kinase-homoserine dehydrogenase, aspartokinase-homoserine dehydrogenase I, bifunctional aspartate kinase-homoserine dehydrogenase, BsHSD, HDH, hom, hom-1, Hom6, homoserine dehydrogenase 1, homoserine dehydrogenase 2, HSD, HSDH, HseDH, More, orf19.2951, PbHSD, SACOL1362, StHSD, thrA, TM_0547, TTHA0489, TtHSD

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.3 homoserine dehydrogenase

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Results	in table
3	Activating Compound
46611	AA Sequence
13	Application
1	CAS Registry Number
20	Cloned(Commentary)
72	Cofactor
8	Crystallization (Commentary)
4	Expression
67	General Information
4	IC50 Value
111	Inhibitors
35	kcat/KM [mM/s]
7	Ki Value [mM]
88	KM Value [mM]
10	Localization
26	Metals/Ions
33	Molecular Weight [Da]
61	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
92	Organism
9	Pathway
50	PDB ID
16	pH Optimum
3	pH Range
2	pH Stability
2	Posttranslational Modification
54	Protein Variants
28	Purification (Commentary)
13	Reaction
3	Reaction Type
87	Reference
1	Renatured (Commentary)
16	Source Tissue
15	Specific Activity [micromol/min/mg]
4	Storage Stability
122	Substrates and Products (Substrate)
34	Subunits
101	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
3	Temperature Range [°C]
9	Temperature Stability [°C]
25	Turnover Number [1/s]

Organism

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Organism on EC 1.1.1.3 - homoserine dehydrogenase

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Arabidopsis thaliana

4 entries

Bacillus methanolicus

2 entries

Bacillus methanolicus MGA3

2 entries

Bacillus subtilis

-

761687

P19582

UniProt

brenda

Bacillus subtilis 168

-

761687

P19582

UniProt

brenda

Candida albicans

-

740860, 761724

Q5AIA2

UniProt

brenda

Candida albicans ATCC MYA-2876

-

761724

Q5AIA2

UniProt

brenda

Candida albicans SC5314 / ATCC MYA-2876

-

740860

Q5AIA2

UniProt

brenda

Chenopodium quinoa

two isozymes

689647

-

-

brenda

Corynebacterium glutamicum

3 entries

Corynebacterium glutamicum ATCC 13032

-

762359

P08499

UniProt

brenda

Corynebacterium glutamicum BCRC 11384

-

762359

P08499

UniProt

brenda

Corynebacterium glutamicum DSM 20300

-

762359

P08499

UniProt

brenda

Corynebacterium glutamicum IWJ001

-

738802

P08499

UniProt

brenda

Corynebacterium glutamicum JCM 1318

-

762359

P08499

UniProt

brenda

Corynebacterium glutamicum LMG 3730

-

762359

P08499

UniProt

brenda

Corynebacterium glutamicum NCIMB 10025

-

762359

P08499

UniProt

brenda

Corynebacterium pekinense

-

741465

-

-

brenda

Corynebacterium pekinense AS1.299

-

741465

-

-

brenda

Escherichia coli

2 entries

Escherichia coli W3110

-

760402

P00561

UniProt

brenda

Glycine max

3 entries

Hordeum vulgare

barley

246382

-

-

brenda

Lactiplantibacillus plantarum

-

670165

-

-

brenda

Mycobacterium leprae

-

740548

P46806

UniProt

brenda

Mycobacterium leprae TN

-

740548

P46806

UniProt

brenda

Paracoccidioides brasiliensis

-

760354, 761712

C1G1C3

UniProt

brenda

Paracoccidioides brasiliensis PB18

-

760354, 761712

C1G1C3

UniProt

brenda

Paracoccidioides lutzii

-

760354

C1GTZ6

UniProt

brenda

Paracoccidioides lutzii Pb01

-

760354

C1GTZ6

UniProt

brenda

Pisum sativum

pea

246382, 246388, 246391

-

-

brenda

Pyrococcus horikoshii

-

741408

O58802

UniProt

brenda

Pyrococcus horikoshii ATCC 700860

-

741408

O58802

UniProt

brenda

Rhodospirillum rubrum

-

246389

-

-

brenda

Ricinus communis

castor bean

246388

-

-

brenda

Saccharomyces cerevisiae

5 entries

Serratia marcescens

also shows aspartase kinase activity

246403

-

-

brenda

Spinacia oleracea

2 entries

Staphylococcus aureus

-

739791, 739804

A0A0H2WVX4

UniProt

brenda

Staphylococcus aureus COL

-

739791, 739804

A0A0H2WVX4

UniProt

brenda

Streptomyces clavuligerus

gene hom

688167

Q56R01

UniProt

brenda

Streptomyces clavuligerus NRRL 3585

gene hom

688167

Q56R01

UniProt

brenda

Sulfurisphaera tokodaii

-

739972, 762453

F9VNG5

UniProt

brenda

Sulfurisphaera tokodaii DSM 16993

-

762453

F9VNG5

UniProt

brenda

Sulfurisphaera tokodaii DSM 16993 / JCM 10545 / NBRC 100140 / 7

-

739972

F9VNG5

UniProt

brenda

Thermophilic bacterium

-

246392

-

-

brenda

Thermotoga maritima

-

760736

Q9WZ17

UniProt

brenda

Thermotoga maritima ATCC 43589

-

760736

Q9WZ17

UniProt

brenda

Thermotoga maritima DSM 3109

-

760736

Q9WZ17

UniProt

brenda

Thermotoga maritima JCM 10099

-

760736

Q9WZ17

UniProt

brenda

Thermus thermophilus

2 entries

Triticum aestivum

wheat

246388

-

-

brenda

Zea mays

corn

246383, 246384, 246385, 246386

-

-

brenda

Arabidopsis thaliana

-

662432

-

-

brenda

Arabidopsis thaliana

bifunctional enzyme showing aspartate dehydrogenase and aspartate kinase activity

642341

-

-

brenda

Arabidopsis thaliana

slightly modified at base 60 c to t, bas 1242 t to g, and base 1403 t to c, the latter modification results in change of Leu468 to Ser; var. Columbia, bifunctional enzyme showing aspartate dehydrogenase and aspartate kinase activity

642340

O81852

TREMBL

brenda

Arabidopsis thaliana

var. Bensheim showing threonine and methionine prototrophy, bifunctional enzyme showing aspartate dehydrogenase and aspartate kinase activity, gene akthr2

657018

-

-

brenda

Bacillus methanolicus

isoform hom-1

710978

D8WXQ1

UniProt

brenda

Bacillus methanolicus

isoform hom-2

710978

D8WXQ2

UniProt

brenda

Bacillus methanolicus MGA3

isoform hom-1

710978

D8WXQ1

UniProt

brenda

Bacillus methanolicus MGA3

isoform hom-2

710978

D8WXQ2

UniProt

brenda

Corynebacterium glutamicum

-

246394

-

-

brenda

Corynebacterium glutamicum

-

738802, 739779, 762359

P08499

UniProt

brenda

Corynebacterium glutamicum

a methionine-producing strain carrying mutations in the hom and the thrB genes

688822

-

-

brenda

Escherichia coli

-

246387, 246390, 246398, 246400, 654640

-

-

brenda

Escherichia coli

-

760402

P00561

UniProt

brenda

Glycine max

-

712490

Q3S3F6

UniProt

brenda

Glycine max

bifunctional aspartokinase-homoserine dehydrogenase AK-HSD-1

712490

O65027

UniProt

brenda

Glycine max

bifunctional aspartokinase-homoserine dehydrogenase AK-HSD-2

712490

O63067

UniProt

brenda

Saccharomyces cerevisiae

-

246396

P31116

Uniprot

brenda

Saccharomyces cerevisiae

-

246397, 246399, 246401

-

-

brenda

Saccharomyces cerevisiae

-

246402

P31116

Uniprot

brenda

Saccharomyces cerevisiae

-

654955

-

-

brenda

Saccharomyces cerevisiae

mutant strain M20-20D and wild-type strain S2207A

657018

-

-

brenda

Spinacia oleracea

also shows aspartase kinase activity

246395

-

-

brenda

Spinacia oleracea

spinach

246395

-

-

brenda

Thermus thermophilus

-

246393

-

-

brenda

Thermus thermophilus

-

761404

Q5SL04

UniProt

brenda