1.1.1.306: S-(hydroxymethyl)mycothiol dehydrogenase

This is an abbreviated version, for detailed information about S-(hydroxymethyl)mycothiol dehydrogenase, go to the full flat file.

Reaction

S-(hydroxymethyl)mycothiol
+
NAD+
=
S-formylmycothiol
+
NADH
+
H+

Synonyms

FD-FA1DH, glutathione-independent formaldehyde dehydrogenase, MD-FALDH, mFADH, MSH-dependent formaldehyde dehydrogenase, mycothiol-dependent formaldehyde dehydroganse, NAD/factor-dependent formaldehyde dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.306 S-(hydroxymethyl)mycothiol dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.306 - S-(hydroxymethyl)mycothiol dehydrogenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
80% inhibition at 5 mM
2-(cyclohexylamino)ethanesulfonic acid-NaOH
-
25 mM at pH 9.0: 80% of the activity compared to 0.1 M diphosphate, pH 9.0
-
acetaldehyde
Cu2+
-
complete inhibition at 1 mM
Glycine-NaOH
-
100 mM at pH 9.0: 40% of the activity compared to 0.1 M diphosphate, pH 9.0
Hg2+
-
complete inhibition at 0.1 mM
KCN
-
55% inhibition at 2 mM
Na2B4O7-HCl
-
100 mM at pH 9.0: no activity
Tris-HCl
-
50 mM at pH 9.0: 80% of the activity compared to 0.1 M diphosphate, pH 9.0