1.1.1.315: 11-cis-retinol dehydrogenase
This is an abbreviated version!
For detailed information about 11-cis-retinol dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.315
-
1.1.1.315
-
retinal
-
retinoids
-
11-cis-retinal
-
chromophore
-
fundus
-
photoreceptors
-
all-trans-retinol
-
albipunctatus
-
cralbp
-
retinaldehyde-binding
-
3alpha-hydroxysteroids
-
retinaldehyde
-
9-cis-retinol
-
androsterone
-
photoisomerization
-
cis-retinols
-
electroretinography
-
11-cis-retinaldehyde
-
17beta-hydroxysteroid
-
17beta
-
medicine
-
punctata
-
interphotoreceptor
-
11-cis-retinoids
-
retinoid-binding
- 1.1.1.315
- retinal
-
retinoids
- 11-cis-retinal
- chromophore
-
fundus
-
photoreceptors
- all-trans-retinol
-
albipunctatus
-
cralbp
-
retinaldehyde-binding
-
3alpha-hydroxysteroids
- retinaldehyde
- 9-cis-retinol
- androsterone
-
photoisomerization
- cis-retinols
-
electroretinography
-
11-cis-retinaldehyde
-
17beta-hydroxysteroid
-
17beta
- medicine
-
punctata
-
interphotoreceptor
-
11-cis-retinoids
-
retinoid-binding
Reaction
Synonyms
11-cis RD, 11-cis-RDH, 11-cis-retinol dehydrogenase, 11-cis-Ro-DH, atRDH, cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase, CRAD, CRAD2, cRDH, EC 5.2.1.3, RDH10, RDH5, retinol dehydrogenase 10
ECTree
Advanced search results
Localization
Localization on EC 1.1.1.315 - 11-cis-retinol dehydrogenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
-
pronounced 11-cis-retinol dehydrogenase activity is associated with both endoplasmic reticulum- and plasma membrane-enriched membrane fractions. In contrast, 11-cis-retinyl ester hydrolase activity is mostly recovered in plasma membrane-enriched fractions, while lecithin retinol acyl transferase LRAT activity is found only in endoplasmic reticulum-enriched membranes
-
pronounced 11-cis-retinol dehydrogenase activity is associated with both endoplasmic reticulum- and plasma membrane-enriched membrane fractions. In contrast, 11-cis-retinyl ester hydrolase activity is mostly recovered in plasma membrane-enriched fractions, while lecithin retinol acyl transferase LRAT activity is found only in endoplasmic reticulum-enriched membranes
the majority of 11-cis retinol dehydrogenase is associated with the smooth ER in retinal pigment epithelial cells. The enzyme is an integral membrane protein, anchored to membranes by two hydrophobic peptide segments. The catalytic domain of the enzyme is confined to a lumenal compartment and is not present on the cytosolic aspect of membranes
wild-type. All tested RDH5 mutants, including A294P, show an abnormal perinuclear localization in transfected cells and induce a redistribution of the ER marker calnexin
associated to membrane, and ssequence displays several potential membrane-spanning segments
-
pronounced 11-cis-retinol dehydrogenase activity is associated with both endoplasmic reticulum- and plasma membrane-enriched membrane fractions. In contrast, 11-cis-retinyl ester hydrolase activity is mostly recovered in plasma membrane-enriched fractions, while lecithin retinol acyl transferase LRAT activity is found only in endoplasmic reticulum-enriched membranes