1.1.1.324: 8-hydroxygeraniol dehydrogenase

This is an abbreviated version!
For detailed information about 8-hydroxygeraniol dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.324

1.1.1.324

indole

roseus

10-hydroxygeraniol

catharanthus

iridoid

monoterpenoids

10-hydroxylase

monooxygenase

nerol

terpenoids

Reaction

Synonyms

10-hydroxygeraniol oxidoreductase, 8-hydroxygeraniol oxidoreductase, 8HGO, acyclic monoterpene primary alcohol:NADP+ oxidoreductase, ADH10, alcohol dehydrogenase 10, Cr10HGO, CrG10H, CYP76B10, G10H, SmG10H

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.324 8-hydroxygeraniol dehydrogenase

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Results	in table
12	AA Sequence
1	Application
1	CAS Registry Number
1	Cloned(Commentary)
4	Cofactor
1	Expression
3	General Information
1	General Stability
9	Inhibitors
1	Ki Value [mM]
2	KM Value [mM]
2	Localization
3	Metals/Ions
4	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
3	Organism
3	Pathway
1	PDB ID
3	pH Optimum
1	pI Value
1	Protein Variants
2	Purification (Commentary)
5	Reaction
3	Reference
5	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
10	Substrates and Products (Substrate)
2	Subunits
14	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Expression

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Expression on EC 1.1.1.324 - 8-hydroxygeraniol dehydrogenase

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the enzyme expression is activated by transcription factor BIS3, i.e. BHLH iridoid synthesis 3, a basic helix-loop-helix (bHLH) transcription factor and key regulators of plant specialized metabolites, including terpenoid indole alkaloids, in Catharanthus roseus plants. BIS3 is clustered with BIS2 and BIS1 in a bHLH gene cluster. Similar to the iridoid pathway genes, BIS3 is highly expressed in roots and induced by methyl jasmonate. Transactivation of the promoters is abolished when BIS3 is converted to a dominant repressor by fusing with the ERF-associated amphiphilic repression (EAR) sequence (BIS3-SRDX)

Catharanthus roseus

W8JWV8

763575