1.1.1.332: chanoclavine-I dehydrogenase

This is an abbreviated version!
For detailed information about chanoclavine-I dehydrogenase, go to the full flat file.

Reaction

Synonyms

ARB_04646, ChaDH, easD, fgaDH, FgaDHPr, ifgE

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.332 chanoclavine-I dehydrogenase

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Results	in table
1	Activating Compound
8	AA Sequence
4	Cloned(Commentary)
10	Cofactor
16	General Information
2	Inhibitors
2	kcat/KM [mM/s]
6	KM Value [mM]
4	Metals/Ions
5	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
11	Organism
3	Pathway
1	Reaction
11	Reference
13	Substrates and Products (Substrate)
2	Subunits
32	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
4	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.1.1.332 - chanoclavine-I dehydrogenase

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FgaOx3Pr3

Penicillium roqueforti

an old yellow enzyme (OYE), does not convert chanoclavine-I aldehyde to its shunt products in the absence of FgaFS. Instead, it increases significantly the product yields of several SDRs for the conversion of chanoclavine-I to its aldehyde. Kinetic studies prove that overcoming the product inhibition is responsible for the observed enhancement. Bifunctionality of OYE and synergistic effect with SDRs

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