1.1.1.333: decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase
This is an abbreviated version!
For detailed information about decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase, go to the full flat file.
Word Map on EC 1.1.1.333
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1.1.1.333
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tuberculosis
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mycobacterium
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benzothiazinones
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arabinogalactan
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arabinans
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smegmatis
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d-arabinose
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mycolate
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dinitrobenzamide
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corynebacterium
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glutamicum
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arabinosylated
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multidrug-resistant
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corynebacterineae
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heteromeric
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xdr-tb
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antituberculosis
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antitubercular
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drug-resistant
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analysis
- 1.1.1.333
- tuberculosis
- mycobacterium
-
benzothiazinones
- arabinogalactan
- arabinans
- smegmatis
- d-arabinose
-
mycolate
-
dinitrobenzamide
-
corynebacterium
- glutamicum
-
arabinosylated
-
multidrug-resistant
- corynebacterineae
-
heteromeric
-
xdr-tb
-
antituberculosis
-
antitubercular
-
drug-resistant
- analysis
Reaction
Synonyms
decaprenylphospho-beta-D-ribofuranose 2'-epimerase, DprE2, MSMEG_6385, Rv3791
ECTree
1.1.1.333 decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductaseAdvanced search results
results (
results (| Results | in table |
|---|---|
| 730 | AA Sequence |
| 2 | Application |
| 1 | Cloned(Commentary) |
| 1 | Cofactor |
| 3 | General Information |
| 2 | Inhibitors |
| 7 | Organism |
| 1 | Pathway |
| 1 | Reaction |
| 5 | Reference |
| 4 | Substrates and Products (Substrate) |
| 7 | Synonyms |
| 1 | Systematic Name |
Inhibitors
Inhibitors on EC 1.1.1.333 - decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
N-(2-(4-methoxyphenoxy)ethyl)-3,5-dinitrobenzamide
more than a ten-fold decrease in the number of colony-forming units is observed with both human and mouse primary cells at a N-(2-(4-methoxyphenoxy)ethyl)-3,5-dinitrobenzamide concentrations above 5 microM, compound is also highly active against multidrug-resistant and extensively drug-resistant clinical isolates. N-(2-(4-methoxyphenoxy)ethyl)-3,5-dinitrobenzamide shows a clear-cut effect on the synthesis of the arabinan domains of arabinogalactan and lipoarabinomannan, and inhibition of decaprenyl-phospho-arabinose formation in the treated extracts concurrent with the accumulation of decaprenylphospho-ribose. Target of the inhibitors is probably the heteromeric decaprenylphospho-ribose 29 epimerase encoded by the dprE1/dprE2 genes
N-(2-(benzyloxy)ethyl)-3,5-dinitrobenzamide
more than a ten-fold decrease in the number of colony-forming units is observed with both human and mouse primary cells at a N-(2-(benzyloxy)ethyl)-3,5-dinitrobenzamide concentrations above 5 microM, compound is also highly active against multidrug-resistant and extensively drug-resistant clinical isolates. N-(2-(benzyloxy)ethyl)-3,5-dinitrobenzamide shows a clear-cut effect on the synthesis of the arabinan domains of arabinogalactan and lipoarabinomannan, and inhibition of decaprenyl-phospho-arabinose formation in the treated extracts concurrent with the accumulation of decaprenylphospho-ribose. Target of the inhibitors is probably the heteromeric decaprenylphospho-ribose 29 epimerase encoded by the dprE1/dprE2 genes
