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1.1.1.334: methylecgonone reductase

This is an abbreviated version!
For detailed information about methylecgonone reductase, go to the full flat file.

Reaction

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ecgonine methyl ester
+
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NADP+
=
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ecgonone methyl ester
+
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NADPH
+
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H+

Synonyms

MecgoR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                EC 1.1.1.3341.1.1.334 methylecgonone reductase

Systematic Name

Systematic Name on EC 1.1.1.334 - methylecgonone reductase

for references in articles please use BRENDA:EC1.1.1.334

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SYSTEMATIC NAME
IUBMB Comments
ecgonine methyl ester:NADP+ oxidoreductase
The enzyme from the plant Erythroxylum coca catalyses the penultimate step in the biosynthesis of cocaine. In vivo the reaction proceeds in the opposite direction. With NADH instead of NADPH the reaction rate is reduced to 14%. The enzyme also reduces tropinone, nortropinone and 6-hydroxytropinone but with lower reaction rates.