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1.1.1.337: L-2-hydroxycarboxylate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about L-2-hydroxycarboxylate dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.1.1.337

Reaction

a (2S)-2-hydroxycarboxylate
+
NAD+
=
a 2-oxocarboxylate
 +
NADH
 +
H+

Synonyms

(R)-sulfolactate dehydrogenase, ComC, L-2-hydroxyacid dehydrogenase, L-2-hydroxyacid dehydrogenase (NAD+), L-2-hydroxyisocaproate dehydrogenase, L-HicDH, L-hydroxyisocaproate dehydrogenase, L-sulfolactate dehydrogenase, MDH I, MJ1425, sulfolactate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)

KM Value

KM Value on EC 1.1.1.337 - L-2-hydroxycarboxylate dehydrogenase (NAD+)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
15
1-oxo-1,3,4,6-hexanetetracarboxylate
cosubstrate NADH, pH 8.0, 70°C
2.2
2-hydroxycaproate
pH 8.0, 30°C
0.62
2-hydroxyisocaproate
pH 8.0, 30°C
0.6
2-Hydroxyisovalerate
pH 8.0, 30°C
1.9
2-Hydroxyoctanoate
pH 8.0, 30°C
1.8
2-hydroxyvalerate
pH 8.0, 30°C
0.45
2-oxobutyrate
pH 7.0, 30°C
0.071 - 62
2-oxocaproate
1.9
2-oxoglutarate
cosubstrate NADH, pH 8.0, 70°C
0.06
2-oxoisocaproate
pH 7.0, 30°C
0.065
2-oxoisovalerate
pH 7.0, 30°C
0.17
2-oxooctanoate
pH 7.0, 30°C
1.9
2-oxopentanedioic acid
pH 8.0, 70°C
0.1
2-oxovalerate
pH 7.0, 30°C
0.64
3-Phenyllactate
pH 8.0, 30°C
0.04 - 0.21
3-sulfopyruvate
0.067 - 110
4-methyl-2-oxopentanoate
46
glyoxylate
pH 8.0, 70°C
100
L-lactate
pH 8.0, 30°C
0.0551
NADH
pH 6.5, 37°C
0.11 - 5.32
oxaloacetate
3.4
oxopropandioic acid
pH 8.0, 70°C
0.026 - 19
phenylpyruvate
2 - 200
pyruvate
0.196
sulfopyruvate
pH 6.5, 37°C
additional information
additional information
typical Michaelis-Menten kinetics, comparison to ComC enzymes from other rumen methanogens from Methanobrevibacter
-