1.1.1.356: GDP-L-colitose synthase

This is an abbreviated version!
For detailed information about GDP-L-colitose synthase, go to the full flat file.

Reaction

Synonyms

ColC

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.356 GDP-L-colitose synthase

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in table

6

AA Sequence

1

Cloned(Commentary)

2

Cofactor

2

KM Value [mM]

2

Molecular Weight [Da]

2

Natural Substrates/ Products (Substrates)

2

Organism

3

Pathway

1

pH Optimum

1

Purification (Commentary)

1

Reaction

2

Reference

1

Storage Stability

6

Substrates and Products (Substrate)

4

Subunits

2

Synonyms

1

Systematic Name

1

Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 1.1.1.356 - GDP-L-colitose synthase

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SYSTEMATIC NAME

IUBMB Comments

GDP-beta-L-colitose:NAD(P)+ 4-oxidoreductase (5-epimerizing)

The enzyme is involved in biosynthesis of L-colitose, a 3,6-dideoxyhexose found in the O-antigen of Gram-negative lipopolysaccharides, where it catalyses the reaction in the reverse direction. The enzyme also performs the NAD(P)H-dependent epimerisation at C-5 of the sugar. The enzyme from Yersinia pseudotuberculosis is Si-specific with respect to NAD(P)H [1].