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1.1.1.364: dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase

This is an abbreviated version!
For detailed information about dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase, go to the full flat file.

Reaction

dTDP-6-deoxy-alpha-D-allose
+
NAD(P)+
=
dTDP-4-dehydro-6-deoxy-alpha-D-gulose
+
NAD(P)H
+
H+

Synonyms

GerKI

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.364 dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase

Natural Substrates Products

Natural Substrates Products on EC 1.1.1.364 - dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dTDP-4-dehydro-6-deoxy-alpha-D-gulopyranose + NADH + H+
dTDP-6-deoxy-alpha-D-allopyranose + NAD+
show the reaction diagram
the enzyme forms an activated deoxy-alpha-D-allose, which is converted to mycinose after attachment to the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II
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