1.1.1.375: L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
This is an abbreviated version!
For detailed information about L-2-hydroxycarboxylate dehydrogenase [NAD(P)+], go to the full flat file.
Word Map on EC 1.1.1.375
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1.1.1.375
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dehydrogenases
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methanococcus
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jannaschii
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l-lactate
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nadh-dependent
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hyperthermophilic
- 1.1.1.375
- dehydrogenases
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methanococcus
- jannaschii
- l-lactate
-
nadh-dependent
-
hyperthermophilic
Reaction
Synonyms
lactate/malate dehydrogenase, LDH-like L-MalDH, MdhII, MJ0409, MJ0490
ECTree
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]Advanced search results
results (
results (Results
in table
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13
21
16
Substrates Products
Substrates Products on EC 1.1.1.375 - L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2S)-3-sulfolactate + NADP+
3-sulfopyruvate + NADPH + H+
weak activity, Vmax/KM: 1/min*mg. The enzyme does not catalyse the oxidation of (2S)-3-sulfolactate with NAD+ as cofactor
-
-
r
3-sulfopyruvate + NADH + H+
(2S)-3-sulfolactate + NAD+
Vmax/KM: 34/min*mg. The enzyme prefers oxaloacetate over 3-sulfopyruvate using NADH as cofactor
-
-
ir
3-sulfopyruvate + NADPH
(2R)-3-sulfolactate + NADP+
the reverse oxidation reaction occurs at least ten to 20 times more slowly. Preference of NADPH over NADH
-
-
?
pyruvate + NADH
(S)-lactate + NAD+
preference of NADPH over NADH. Activity is detected only when the allosteric activator fructose-1,6-bisphosphate is added to the assay mixture
-
-
?
pyruvate + NADPH
(S)-lactate + NADP+
preference of NADPH over NADH. Activity is detected only when the allosteric activator fructose-1,6-bisphosphate is added to the assay mixture
-
-
?
(S)-malate + NAD+
oxaloacetate + NADH + H+
Vmax/KM: 4/min*mg. The enzyme prefers NADP+ over NAD+ in oxidation of (S)-malate
-
-
r
(S)-malate + NAD+
oxaloacetate + NADH + H+
Vmax/KM: 4/min*mg. The enzyme prefers NADP+ over NAD+ in oxidation of (S)-malate
-
-
r
(S)-malate + NAD+
oxaloacetate + NADH + H+
-
-
-
?
(S)-malate + NADP+
oxaloacetate + NADPH + H+
Vmax/KM: 110/min*mg. The enzyme prefers NADP+ over NAD+ in oxidation of (S)-malate
-
-
r
(S)-malate + NADP+
oxaloacetate + NADPH + H+
Vmax/KM: 110/min*mg. The enzyme prefers NADP+ over NAD+ in oxidation of (S)-malate
-
-
r
3-sulfopyruvate + NADH
(2R)-3-sulfolactate + NAD+
preference of NADPH over NADH
-
-
?
3-sulfopyruvate + NADH
(2R)-3-sulfolactate + NAD+
preference of NADPH over NADH
-
-
?
3-sulfopyruvate + NADPH + H+
(2S)-3-sulfolactate + NADP+
-
-
-
r
3-sulfopyruvate + NADPH + H+
(2S)-3-sulfolactate + NADP+
Vmax/KM: 590/min*mg. The enzyme prefers NADPH over NADH in reduction of 3-sulfopyruvate
-
-
r
oxaloacetate + NADH
(S)-malate + NAD+
preference of NADPH over NADH
-
-
r
oxaloacetate + NADH
(S)-malate + NAD+
preference of NADPH over NADH
-
-
r
oxaloacetate + NADH + H+
(S)-malate + NAD+
Vmax/KM: 120 /min*mg. The enzyme prefers oxaloacetate over 3-sulfopyruvate using NADH as cofactor. The enzyme prefers NADPH over NADH in reduction of oxaloacetate
-
-
r
oxaloacetate + NADH + H+
(S)-malate + NAD+
Vmax/KM: 120 /min*mg. The enzyme prefers oxaloacetate over 3-sulfopyruvate using NADH as cofactor. The enzyme prefers NADPH over NADH in reduction of oxaloacetate
-
-
r
oxaloacetate + NADH + H+
(S)-malate + NAD+
-
-
-
r
oxaloacetate + NADPH
(S)-malate + NADP+
the reverse oxidation reaction occurs at least ten to 20 times more slowly. Preference of NADPH over NADH
-
-
r
oxaloacetate + NADPH
(S)-malate + NADP+
the reverse oxidation reaction occurs at least ten to 20 times more slowly. Preference of NADPH over NADH
-
-
r
oxaloacetate + NADPH + H+
(S)-malate + NADP+
Vmax/KM: 160/min*mg. The enzyme prefers NADPH over NADH in reduction of oxaloacetate
-
-
r
oxaloacetate + NADPH + H+
(S)-malate + NADP+
Vmax/KM: 160/min*mg. The enzyme prefers NADPH over NADH in reduction of oxaloacetate
-
-
r
oxaloacetate + NADPH + H+
(S)-malate + NADP+
-
-
-
r
pyruvate + NADH + H+
(S)-lactate + NAD+
ratio of reaction rates for NADPH and NADH is 1.3-1.6 in the temperature range of 30-60°C (with 0.4 mM fructose 1,6-bisphosphate). The enzymatic activity for the oxidation reaction can not be measured under the tested conditions
-
-
ir
pyruvate + NADH + H+
(S)-lactate + NAD+
ratio of reaction rates for NADPH and NADH is 1.3-1.6 in the temperature range of 30-60°C (with 0.4 mM fructose 1,6-bisphosphate). The enzymatic activity for the oxidation reaction can not be measured under the tested conditions
-
-
ir
pyruvate + NADPH + H+
(S)-lactate + NADP+
ratio of reaction rates for NADPH and NADH is 1.3-1.6 in the temperature range of 30-60°C (with 0.4 mM fructose 1,6-bisphosphate). The enzymatic activity for the oxidation reaction can not be measured under the tested conditions
-
-
ir
pyruvate + NADPH + H+
(S)-lactate + NADP+
ratio of reaction rates for NADPH and NADH is 1.3-1.6 in the temperature range of 30-60°C (with 0.4 mM fructose 1,6-bisphosphate). The enzymatic activity for the oxidation reaction can not be measured under the tested conditions
-
-
ir
additional information
?
-
no activity with 2-oxoglutarate and 1-oxo-1,3,4,6-hexanetetracarboxylic acid
-
-
?
additional information
?
-
-
no activity with 2-oxoglutarate and 1-oxo-1,3,4,6-hexanetetracarboxylic acid
-
-
?
additional information
?
-
no activity with 2-oxoglutarate and 1-oxo-1,3,4,6-hexanetetracarboxylic acid
-
-
?
