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BRENDA support L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

This is an abbreviated version!
For detailed information about L-2-hydroxycarboxylate dehydrogenase [NAD(P)+], go to the full flat file.

Word Map on EC


a (2S)-2-hydroxycarboxylate
a 2-oxocarboxylate


lactate/malate dehydrogenase, LDH-like L-MalDH, MdhII, MJ0409, MJ0490


     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
       L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

Systematic Name

Systematic Name on EC - L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

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IUBMB Comments
(2S)-2-hydroxycarboxylate:NAD(P)+ oxidoreductase
The enzyme from the archaeon Methanocaldococcus jannaschii catalyses the reversible oxidation of (2R)-3-sulfolactate and (S)-malate to 3-sulfopyruvate and oxaloacetate, respectively (note that (2R)-3-sulfolactate has the same stereochemical configuration as (2S)-2-hydroxycarboxylates) [1]. The enzyme can use both NADH and NADPH, although activity is higher with NADPH [1-3]. The oxidation of (2R)-3-sulfolactate was observed only in the presence of NADP+ [1]. The same organism also possesses an NAD+-specific enzyme with similar activity, cf. EC, L-2-hydroxycarboxylate dehydrogenase (NAD+).