126.96.36.1995: L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
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For detailed information about L-2-hydroxycarboxylate dehydrogenase [NAD(P)+], go to the full flat file.
Word Map on EC 188.8.131.525
lactate/malate dehydrogenase, LDH-like L-MalDH, MdhII, MJ0409, MJ0490
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Systematic Name on EC 184.108.40.2065 - L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
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The enzyme from the archaeon Methanocaldococcus jannaschii catalyses the reversible oxidation of (2R)-3-sulfolactate and (S)-malate to 3-sulfopyruvate and oxaloacetate, respectively (note that (2R)-3-sulfolactate has the same stereochemical configuration as (2S)-2-hydroxycarboxylates) . The enzyme can use both NADH and NADPH, although activity is higher with NADPH [1-3]. The oxidation of (2R)-3-sulfolactate was observed only in the presence of NADP+ . The same organism also possesses an NAD+-specific enzyme with similar activity, cf. EC 220.127.116.117, L-2-hydroxycarboxylate dehydrogenase (NAD+).