1.1.1.375: L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

This is an abbreviated version!
For detailed information about L-2-hydroxycarboxylate dehydrogenase [NAD(P)+], go to the full flat file.

Word Map on EC 1.1.1.375

1.1.1.375

dehydrogenases

methanococcus

jannaschii

l-lactate

nadh-dependent

hyperthermophilic

Reaction

Synonyms

lactate/malate dehydrogenase, LDH-like L-MalDH, MdhII, MJ0409, MJ0490

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Systematic Name

print visible entries

print all entries

Systematic Name on EC 1.1.1.375 - L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Systematic Name Search

(2S)-2-hydroxycarboxylate:NAD(P)+ oxidoreductase

The enzyme from the archaeon Methanocaldococcus jannaschii catalyses the reversible oxidation of (2R)-3-sulfolactate and (S)-malate to 3-sulfopyruvate and oxaloacetate, respectively (note that (2R)-3-sulfolactate has the same stereochemical configuration as (2S)-2-hydroxycarboxylates) [1]. The enzyme can use both NADH and NADPH, although activity is higher with NADPH [1-3]. The oxidation of (2R)-3-sulfolactate was observed only in the presence of NADP+ [1]. The same organism also possesses an NAD+-specific enzyme with similar activity, cf. EC 1.1.1.337, L-2-hydroxycarboxylate dehydrogenase (NAD+).