1.1.1.381: 3-hydroxy acid dehydrogenase

This is an abbreviated version!
For detailed information about 3-hydroxy acid dehydrogenase, go to the full flat file.

Reaction

Synonyms

ydfG, YMR226c

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.381 3-hydroxy acid dehydrogenase

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Results

in table

855

AA Sequence

2

Cloned(Commentary)

2

Cofactor

15

KCat/KM [mM/s]

16

KM Value [mM]

3

Organism

2

Pathway

2

pH Optimum

2

pH Stability

2

Purification (Commentary)

3

Reaction

3

Reference

2

Specific Activity [micromol/min/mg]

20

Substrates and Products (Substrate)

4

Synonyms

1

Systematic Name

2

Temperature Optimum [�C]

2

Temperature Stability [�C]

15

Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.1.1.381 - 3-hydroxy acid dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

L-allo-threonine:NADP+ 3-oxidoreductase

The enzyme, purified from the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae, shows activity with a range of 3- and 4-carbon 3-hydroxy acids. The highest activity is seen with L-allo-threonine and D-threonine. The enzyme from Escherichia coli also shows high activity with L-serine, D-serine, (S)-3-hydroxy-2-methylpropanoate and (R)-3-hydroxy-2-methylpropanoate. The enzyme has no activity with NAD+ or L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase).