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1.1.1.382: ketol-acid reductoisomerase (NAD+)

This is an abbreviated version!
For detailed information about ketol-acid reductoisomerase (NAD+), go to the full flat file.

Reaction

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(2R)-2,3-dihydroxy-3-methylbutanoate
+
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NAD+
=
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(2S)-2-hydroxy-2-methyl-3-oxobutanoate
+
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NADH
+
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H+

Synonyms

ilvC

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                EC 1.1.1.3821.1.1.382 ketol-acid reductoisomerase (NAD+)

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Resultsin table
43AA Sequence
4Cloned(Commentary)
4Cofactor
4Crystallization (Commentary)
4kcat/KM [mM/s]
4KM Value [mM]
9Organism
4pH Optimum
4Purification (Commentary)
1Reaction
9Reference
4Substrates and Products (Substrate)
4Synonyms
1Systematic Name
4Turnover Number [1/s]
All data fields related to EC 1.1.1.382

Reference

Reference on EC 1.1.1.382 - ketol-acid reductoisomerase (NAD+)

for references in articles please use BRENDA:EC1.1.1.382

Please use the Reference Search for a specific query.

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cahn, J.K.; Brinkmann-Chen, S.; Spatzal, T.; Wiig, J.A.; Buller, A.R.; Einsle, O.; Hu, Y.; Ribbe, M.W.; Arnold, F.H.
Cofactor specificity motifs and the induced fit mechanism in Class I ketol-acid reductoisomerases
Biochem. J.
468
475-484
2015
Alicyclobacillus acidocaldarius subsp. acidocaldarius (C8WR67), Ignisphaera aggregans (E0SRA9), Ignisphaera aggregans DSM 17230 (E0SRA9), uncultured archaeon (Q64BR7), uncultured archaeon GZfos26G2 (Q64BR7)
Manually annotated by BRENDA team
Brinkmann-Chen, S.; Cahn, J.K.; Arnold, F.H.
Uncovering rare NADH-preferring ketol-acid reductoisomerases
Metab. Eng.
26C
17-22
2014
Archaeoglobus fulgidus (O28294), Desulfosudis oleivorans, Thermacetogenium phaeum, uncultured archaeon
Manually annotated by BRENDA team