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1.1.1.391: 3beta-hydroxycholanate 3-dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about 3beta-hydroxycholanate 3-dehydrogenase (NAD+), go to the full flat file.

Reaction

isolithocholate
+
NAD+
=
3-oxo-5beta-cholan-24-oate
+
NADH
+
H+

Synonyms

3beta-HSD, 3beta-HSDH, 3beta-hydroxysteroid dehydrogenase, bile acid 3beta-HSD, iso bile acid dehydrogenase, NAD-dependent 3beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.391 3beta-hydroxycholanate 3-dehydrogenase (NAD+)

Inhibitors

Inhibitors on EC 1.1.1.391 - 3beta-hydroxycholanate 3-dehydrogenase (NAD+)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-oxo bile acids
-
the specific enzyme activity is significantly reduced by growth medium supplementation with 3-oxo bile acids, with trisubstituted acids being more effective than disubstituted ones
-
Bile acids
-
specific enzymatic activities are significantly reduced when bacteria are grown in the presence of 3-oxo bile acids, while other bile acids are ineffective