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1.1.1.393: 3beta-hydroxycholanate 3-dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about 3beta-hydroxycholanate 3-dehydrogenase (NADP+), go to the full flat file.

Reaction

isolithocholate
+
NADP+
=
3-oxo-5beta-cholan-24-oate
+
NADPH
+
H+

Synonyms

3beta-HSDH, 3beta-hydroxysteroid dehydrogenase, 3beta-hyoxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.393 3beta-hydroxycholanate 3-dehydrogenase (NADP+)

Reference

Reference on EC 1.1.1.393 - 3beta-hydroxycholanate 3-dehydrogenase (NADP+)

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chen, M.; Drury, J.E.; Christianson, D.W.; Penning, T.M.
Conversion of human steroid 5beta-reductase (AKR1D1) into 3beta-hydroxysteroid dehydrogenase by single point mutation E120H: example of perfect enzyme engineering
J. Biol. Chem.
287
16609-16622
2012
Ruminococcus sp., Ruminococcus sp. PO1-3
Manually annotated by BRENDA team
Devlin, A.; Fischbach, M.
A biosynthetic pathway for a prominent class of microbiota-derived bile acids
Nat. Chem. Biol.
11
685-690
2015
[Ruminococcus] gnavus (A7AZH2), [Ruminococcus] gnavus ATCC 29149 (A7AZH2)
Manually annotated by BRENDA team