1.1.1.395: 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase

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For detailed information about 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase, go to the full flat file.

Reaction

Synonyms

3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase, baiA1, baiA2, baiA3, bile acid-inducible 3 alpha-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.395 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase

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Results

in table

77

AA Sequence

3

Cloned(Commentary)

2

Cofactor

1

Crystallization (Commentary)

30

kcat/KM [mM/s]

30

KM Value [mM]

2

Molecular Weight [Da]

4

Natural Substrates/ Products (Substrates)

38

Organism

3

Pathway

2

Protein Variants

2

Purification (Commentary)

1

Reaction

8

Reference

24

Substrates and Products (Substrate)

3

Subunits

20

Synonyms

1

Systematic Name

30

Turnover Number [1/s]

Engineering

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Engineering on EC 1.1.1.395 - 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

E42A

2 entries

E42A

[Clostridium] scindens

P19337

the mutation improves specificity toward NADP+ by 10fold compared to the wild type enzyme

739615

E42A

[Clostridium] scindens VPI 12708

-

the mutation improves specificity toward NADP+ by 10fold compared to the wild type enzyme

-