1.1.1.395: 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase

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For detailed information about 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase, go to the full flat file.

Reaction

Synonyms

3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase, baiA1, baiA2, baiA3, bile acid-inducible 3 alpha-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.395 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase

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in table

77

AA Sequence

3

Cloned(Commentary)

2

Cofactor

1

Crystallization (Commentary)

2

Engineering

30

KCat/KM [mM/s]

30

KM Value [mM]

2

Molecular Weight [Da]

4

Natural Substrates/ Products (Substrates)

38

Organism

3

Pathway

2

Purification (Commentary)

1

Reaction

8

Reference

24

Substrates and Products (Substrate)

3

Subunits

20

Synonyms

1

Systematic Name

30

Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.1.1.395 - 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

3alpha-hydroxy-bile-acid-CoA-ester:NAD+ 3-oxidoreductase

This bacterial enzyme is involved in the 7-dehydroxylation process associated with bile acid degradation. The enzyme has very little activity with unconjugated bile acid substrates. It has similar activity with choloyl-CoA, chenodeoxycholoyl-CoA, deoxycholoyl-CoA, and lithocholoyl-CoA.