1.1.1.4: (R,R)-butanediol dehydrogenase

This is an abbreviated version!
For detailed information about (R,R)-butanediol dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.4

Reaction

(R,R)-butane-2,3-diol
+
NAD+
=
(R)-acetoin
+
NADH
+
H+

Synonyms

(2R,3R)-2,3-BDH, (2R,3R)-2,3-butanediol dehydrogenase, (R)-2,3-butanediol dehydrogenase, (R)-diacetyl reductase, (R,R)-butane-2,3-diol dehydrogenase, 1-amino-2-propanol dehydrogenase, 1-amino-2-propanol oxidoreductase, 2,3-BDH/AR, 2,3-butanediol dehydrogenase, 2,3-butanediol dehydrogenase/acetoin reductase, 2R,3R-2,3-BD dehydrogenase, 2R-3R-BDH, acetoin reductase, acetoin/diacetyl reductase, ADH-9, aminopropanol oxidoreductase, AR/BDH, BaBdhA, BcBDH, BDH, BDH1, Bdh1p, BDH2, Bdh2p, BDH99::67, BdhA, BtBDH, ButA, butanediol dehydrogenase, ButB, butylene glycol dehydrogenase, butyleneglycol dehydrogenase, D-(-)-butanediol dehydrogenase, D-1-amino-2-propanol dehydrogenase, D-1-amino-2-propanol:NAD+ oxidoreductase, D-2,3-BD dehydrogenase, D-aminopropanol dehydrogenase, dehydrogenase, D-aminopropanol, dehydrogenase, D-butanediol, DHAD, diacetyl reductase (acetoin), EC 1.1.1.74, GDH, GldA, meso-2,3-butanediol dehydrogenase, meso-BDH, MF996569, More, NAD(H)-dependent 2,3-butanediol dehydrogenase, NADH-dependent 2,3-butanediol dehydrogenase, PA4153, PB24_3312, R,R-2,3-butanediol dehydrogenase/meso-2,3-butanediol dehydrogenase/diacetyl reductase, R,R-BD-DH, R,R-BDH, R-selective 2,3-butanediol dehydrogenase, SLAC

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.4 (R,R)-butanediol dehydrogenase

Specific Activity

Specific Activity on EC 1.1.1.4 - (R,R)-butanediol dehydrogenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.004
-
with (2S,3s)-butane-2,3-diol as substrate, at pH 7.4 and 30°C
0.005
-
with pentane-1,2-diol as substrate, at pH 7.4 and 30°C
0.007
-
with butanone as substrate, at pH 7.4 and 30°C
0.01
-
with pentane-2,3-dione as substrate, at pH 7.4 and 30°C
0.012
-
with hexane-2,5-dione as substrate, at pH 7.4 and 30°C
0.019
-
with pentane-2,4-dione as substrate, at pH 7.4 and 30°C
0.044
-
with n-butyöaödehyde as substrate, at pH 7.4 and 30°C
0.048
-
with butane-1,2-diol as substrate, at pH 7.4 and 30°C
0.084
-
with diacetyl as substrate, at pH 7.4 and 30°C
0.093
-
with propane-1,2-diol as substrate, at pH 7.4 and 30°C
0.1
wild type enzyme, using 1 mM NADPH as cosubstrate
0.155
pH 7.4, 30°C, substrate propane-1,2-diol
0.24
purified recombinant enzyme, pH 7.0, 30°C, substrates glycolaldehyde and NADPH
0.257
-
with 1-hydroxy-2-butanone as substrate, at pH 7.4 and 30°C
0.331
pH 7.4, 30°C, substrate 1-hydroxy-2-butanone
0.383
pH 7.4, 30°C, substrate butane-1,2-diol
0.48
purified recombinant enzyme, pH 7.0, 30°C, substrates formaldehyde and NADPH
0.732
-
with 1,3-dihydroxyacetone as substrate, at pH 7.4 and 30°C
0.76
purified recombinant enzyme, pH 7.0, 30°C, substrates formaldehyde and NADPH
0.82
purified recombinant enzyme, pH 7.0, 30°C, substrates furfural and NADPH
1.056
-
with (2R,3R)-butane-2,3-diol as substrate, at pH 7.4 and 30°C
1.16
purified recombinant enzyme, pH 7.0, 30°C, substrates hexaldehyde and NADH
1.179
pH 7.4, 30°C, substrate (2R,3S)-butane-2,3-diol
1.193
-
with (R)-acetoin as substrate, at pH 7.4 and 30°C
1.3
purified recombinant enzyme, pH 7.0, 30°C, substrates formaldehyde and NADH
1.346
pH 7.4, 30°C, substrate 2,3-pentanedione
1.538
pH 7.4, 30°C, substrate (2R,3R)-butane-2,3-diol
1.71
purified recombinant enzyme, pH 7.0, 30°C, substrates formaldehyde and NADH
1.94
purified recombinant enzyme, pH 7.0, 30°C, substrates propionaldehyde and NADH
1.949
pH 7.4, 30°C, substrate rac acetoin
10.2
purified recombinant enzyme, pH 7.0, 30°C, substrates glycolaldehyde and NADH
10.48
-
crude enzyme, with substrate (3S/3R)-acetoin and NADH at room temperature, pH 8.0, 22°C
117.95
purified recombinant enzyme, pH 7.0, 30°C, substrates acetaldehyde and NADH
13.7
mutant enzyme E221S, using 1 mM NADPH as cosubstrate
2.154
pH 7.4, 30°C, substrate diacetyl
2.47
purified recombinant enzyme, pH 7.0, 30°C, substrates hexaldehyde and NADH
2.72
purified recombinant enzyme, pH 7.0, 30°C, substrates acetaldehyde and NADPH
2.74
purified recombinant enzyme, pH 7.0, 30°C, substrates furfural and NADH
20.75
-
purified enzyme, with substrate (3S/3R)-acetoin and NADH at room temperature, pH 8.0, 22°C
3.44
purified recombinant enzyme, pH 7.0, 30°C, substrates acetaldehyde and NADPH
35.55
-
diacetyl, enzyme 2
35.6
-
diacetyl, enzyme 1
4.1
mutant enzyme E221S, using 1 mM NADH as cosubstrate
4.65
-
purified native enzyme, pH 7.0, 30°C
4.8
mutant enzyme E221S/I222R, using 1 mM NADH as cosubstrate
4.95
purified recombinant enzyme, pH 7.0, 30°C, substrates furfural and NADH
5.1
-
acetoin, enzyme 1
54.7
mutant enzyme E221S/I222R, using 1 mM NADPH as cosubstrate
6.1
mutant enzyme E221S/I222R/A223S, using 1 mM NADH as cosubstrate
6.27
purified recombinant enzyme, pH 7.0, 30°C, substrates glycolaldehyde and NADH
7.55
-
acetoin, enzyme 2
78.58
purified recombinant enzyme, pH 7.0, 30°C, substrates acetaldehyde and NADH
92
wild type enzyme, using 1 mM NADH as cosubstrate
93.2
mutant enzyme E221S/I222R/A223S, using 1 mM NADPH as cosubstrate
additional information