1.1.1.4: (R,R)-butanediol dehydrogenase

This is an abbreviated version!
For detailed information about (R,R)-butanediol dehydrogenase, go to the full flat file.

Reaction

Synonyms

(2R,3R)-2,3-BDH, (2R,3R)-2,3-butanediol dehydrogenase, (R)-2,3-butanediol dehydrogenase, (R)-diacetyl reductase, (R,R)-butane-2,3-diol dehydrogenase, 1-amino-2-propanol dehydrogenase, 1-amino-2-propanol oxidoreductase, 2,3-BDH/AR, 2,3-butanediol dehydrogenase, 2,3-butanediol dehydrogenase/acetoin reductase, 2R,3R-2,3-BD dehydrogenase, 2R-3R-BDH, acetoin reductase, acetoin/diacetyl reductase, ADH-9, aminopropanol oxidoreductase, AR/BDH, BaBdhA, BcBDH, BDH, BDH1, Bdh1p, BDH2, Bdh2p, BDH99::67, BdhA, BtBDH, ButA, butanediol dehydrogenase, ButB, butylene glycol dehydrogenase, butyleneglycol dehydrogenase, D-(-)-butanediol dehydrogenase, D-1-amino-2-propanol dehydrogenase, D-1-amino-2-propanol:NAD+ oxidoreductase, D-2,3-BD dehydrogenase, D-aminopropanol dehydrogenase, dehydrogenase, D-aminopropanol, dehydrogenase, D-butanediol, DHAD, diacetyl reductase (acetoin), EC 1.1.1.74, GDH, GldA, meso-2,3-butanediol dehydrogenase, meso-BDH, MF996569, More, NAD(H)-dependent 2,3-butanediol dehydrogenase, NADH-dependent 2,3-butanediol dehydrogenase, PA4153, PB24_3312, R,R-2,3-butanediol dehydrogenase/meso-2,3-butanediol dehydrogenase/diacetyl reductase, R,R-BD-DH, R,R-BDH, R-selective 2,3-butanediol dehydrogenase, SLAC

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.4 (R,R)-butanediol dehydrogenase

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Results

in table

3

Activating Compound

554

AA Sequence

7

Application

1

CAS Registry Number

34

Cloned(Commentary)

75

Cofactor

2

Crystallization (Commentary)

28

Engineering

5

Expression

48

General Information

36

Inhibitors

52

KCat/KM [mM/s]

106

KM Value [mM]

25

Metals/Ions

23

Molecular Weight [Da]

83

Natural Substrates/ Products (Substrates)

2

Organic Solvent Stability

427

Organism

5

Pathway

4

PDB ID

36

pH Optimum

3

pH Range

5

pH Stability

2

pI Value

22

Purification (Commentary)

1

Reaction

3

Reaction Type

97

Reference

10

Source Tissue

61

Specific Activity [micromol/min/mg]

3

Storage Stability

330

Substrates and Products (Substrate)

32

Subunits

212

Synonyms

1

Systematic Name

19

Temperature Optimum [°C]

1

Temperature Range [°C]

8

Temperature Stability [°C]

48

Turnover Number [1/s]

Synonyms

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Synonyms on EC 1.1.1.4 - (R,R)-butanediol dehydrogenase

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

(2R,3R)-2,3-BDH

8 entries

(2R,3R)-2,3-butanediol dehydrogenase

26 entries

(R)-2,3-butanediol dehydrogenase

Saccharomyces cerevisiae

-

-

246410

(R)-diacetyl reductase

-

-

-

-

(R,R)-butane-2,3-diol dehydrogenase

2 entries

1-amino-2-propanol dehydrogenase

-

-

-

-

1-amino-2-propanol oxidoreductase

-

-

-

-

2,3-BDH/AR

2 entries

2,3-butanediol dehydrogenase

16 entries

2,3-butanediol dehydrogenase/acetoin reductase

2 entries

2R,3R-2,3-BD dehydrogenase

2 entries

2R-3R-BDH

2 entries

acetoin reductase

5 entries

acetoin/diacetyl reductase

2 entries

ADH-9

Haloarcula marismortui

-

-

738878

aminopropanol oxidoreductase

-

-

-

-

AR/BDH

Bacillus subtilis

-

-

695754

BaBdhA

2 entries

BcBDH

2 entries

BDH

26 entries

BDH1

8 entries

Bdh1p

4 entries

BDH2

2 entries

Bdh2p

2 entries

BDH99::67

2 entries

BdhA

11 entries

BtBDH

2 entries

ButA

2 entries

butanediol dehydrogenase

6 entries

ButB

2 entries

butylene glycol dehydrogenase

-

-

-

-

butyleneglycol dehydrogenase

-

-

-

-

D-(-)-butanediol dehydrogenase

-

-

-

-

D-1-amino-2-propanol dehydrogenase

-

-

-

-

D-1-amino-2-propanol:NAD+ oxidoreductase

-

-

-

-

D-2,3-BD dehydrogenase

2 entries

D-aminopropanol dehydrogenase

-

-

-

-

dehydrogenase, D-aminopropanol

-

-

-

-

dehydrogenase, D-butanediol

-

-

-

-

DHAD

2 entries

diacetyl reductase (acetoin)

-

-

-

-

EC 1.1.1.74

-

-

formerly

-

GDH

2 entries

GldA

2 entries

meso-2,3-butanediol dehydrogenase

4 entries

meso-BDH

Bacillus licheniformis

-

-

738472

MF996569

2 entries

NAD(H)-dependent 2,3-butanediol dehydrogenase

Saccharomyces cerevisiae

P39714

-

696883

NADH-dependent 2,3-butanediol dehydrogenase

Saccharomyces cerevisiae

-

-

695776

PA4153

8 entries

PB24_3312

2 entries

R,R-2,3-butanediol dehydrogenase/meso-2,3-butanediol dehydrogenase/diacetyl reductase

2 entries

R,R-BD-DH

5 entries

R,R-BDH

2 entries

R-selective 2,3-butanediol dehydrogenase

2 entries

SLAC

2 entries

additional information

10 entries

(2R,3R)-2,3-BDH

Pseudomonas aeruginosa

Q9HWM8

-

756608

(2R,3R)-2,3-BDH

Pseudomonas aeruginosa 1C

Q9HWM8

-

-

(2R,3R)-2,3-BDH

Pseudomonas aeruginosa ATCC 15692

Q9HWM8

-

-

(2R,3R)-2,3-BDH

Pseudomonas aeruginosa CIP 104116

Q9HWM8

-

-

(2R,3R)-2,3-BDH

Pseudomonas aeruginosa DSM 22644

Q9HWM8

-

-

(2R,3R)-2,3-BDH

Pseudomonas aeruginosa JCM 14847

Q9HWM8

-

-

(2R,3R)-2,3-BDH

Pseudomonas aeruginosa LMG 12228

Q9HWM8

-

-

(2R,3R)-2,3-BDH

Pseudomonas aeruginosa PRS 101

Q9HWM8

-

-

(2R,3R)-2,3-butanediol dehydrogenase

Bacillus coagulans

-

-

737366

(2R,3R)-2,3-butanediol dehydrogenase

Bacillus coagulans 2-6

-

-

-

(2R,3R)-2,3-butanediol dehydrogenase

Bacillus subtilis

-

-

738800

(2R,3R)-2,3-butanediol dehydrogenase

Bacillus subtilis 168

-

-

-

(2R,3R)-2,3-butanediol dehydrogenase

Bacillus thuringiensis serovar kurstaki

A0A0F6FX23

-

760463

(2R,3R)-2,3-butanediol dehydrogenase

Bacillus thuringiensis serovar kurstaki ACCC 10066

A0A0F6FX23

-

-

(2R,3R)-2,3-butanediol dehydrogenase

Mycobacterium sp.

F1T242

-

721872

(2R,3R)-2,3-butanediol dehydrogenase

Mycobacterium sp. B-009

F1T242

-

-

(2R,3R)-2,3-butanediol dehydrogenase

Mycolicibacterium gilvum

-

-

721872

(2R,3R)-2,3-butanediol dehydrogenase

Mycolicibacterium smegmatis

-

-

721872

(2R,3R)-2,3-butanediol dehydrogenase

Mycolicibacterium vanbaalenii

-

-

721872

(2R,3R)-2,3-butanediol dehydrogenase

Paenibacillus polymyxa

E7EKB8

-

721345

(2R,3R)-2,3-butanediol dehydrogenase

Paenibacillus polymyxa ATCC 12321

E7EKB8

-

-

(2R,3R)-2,3-butanediol dehydrogenase

Pseudomonas aeruginosa

Q9HWM8

-

756608

(2R,3R)-2,3-butanediol dehydrogenase

Pseudomonas aeruginosa 1C

Q9HWM8

-

-

(2R,3R)-2,3-butanediol dehydrogenase

Pseudomonas aeruginosa ATCC 15692

Q9HWM8

-

-

(2R,3R)-2,3-butanediol dehydrogenase

Pseudomonas aeruginosa CIP 104116

Q9HWM8

-

-

(2R,3R)-2,3-butanediol dehydrogenase

Pseudomonas aeruginosa DSM 22644

Q9HWM8

-

-

(2R,3R)-2,3-butanediol dehydrogenase

Pseudomonas aeruginosa JCM 14847

Q9HWM8

-

-

(2R,3R)-2,3-butanediol dehydrogenase

Pseudomonas aeruginosa LMG 12228

Q9HWM8

-

-

(2R,3R)-2,3-butanediol dehydrogenase

Pseudomonas aeruginosa PRS 101

Q9HWM8

-

-

(2R,3R)-2,3-butanediol dehydrogenase

Rhodococcus erythropolis

A0A0E4A9D6

-

739127

(2R,3R)-2,3-butanediol dehydrogenase

Rhodococcus erythropolis WZ010

A0A0E4A9D6

-

-

(2R,3R)-2,3-butanediol dehydrogenase

Saccharomyces cerevisiae

A0A7G4NVP1, A0A7G4NVP2

-

760423

(2R,3R)-2,3-butanediol dehydrogenase

Saccharomyces cerevisiae

P39714

-

696883

(2R,3R)-2,3-butanediol dehydrogenase

Saccharomyces cerevisiae YBA_08

A0A7G4NVP1, A0A7G4NVP2

-

-

(R,R)-butane-2,3-diol dehydrogenase

Alkalihalobacillus clausii

A0A223LRZ7

-

762382

(R,R)-butane-2,3-diol dehydrogenase

Alkalihalobacillus clausii DSM 8716T

A0A223LRZ7

-

-

2,3-BDH/AR

Corynebacterium crenatum

-

-

738953

2,3-BDH/AR

Corynebacterium crenatum SYPA5-5

-

-

-

2,3-butanediol dehydrogenase

-

-

-

-

2,3-butanediol dehydrogenase

Bacillus amyloliquefaciens

S6FPW0

-

760716

2,3-butanediol dehydrogenase

Bacillus amyloliquefaciens UCMB5033

S6FPW0

-

-

2,3-butanediol dehydrogenase

Bacillus subtilis

-

-

695754

2,3-butanediol dehydrogenase

Bacillus subtilis

O34788

-

762259

2,3-butanediol dehydrogenase

Bacillus subtilis BS168D

O34788

-

-

2,3-butanediol dehydrogenase

Bacillus subtilis subsp. subtilis

O34788

-

761565, 761834

2,3-butanediol dehydrogenase

Bacillus subtilis subsp. subtilis 168

O34788

-

-

2,3-butanediol dehydrogenase

Corynebacterium glutamicum

-

-

737512

2,3-butanediol dehydrogenase

Corynebacterium glutamicum ATCC 13032

-

-

-

2,3-butanediol dehydrogenase

Paenibacillus polymyxa

-

-

722559

2,3-butanediol dehydrogenase

Paenibacillus polymyxa ZJ-9

-

-

-

2,3-butanediol dehydrogenase

Saccharomyces uvarum

-

-

761646

2,3-butanediol dehydrogenase

Saccharomyces uvarum WY1

-

-

-

2,3-butanediol dehydrogenase

Serratia marcescens

-

-

740827

2,3-butanediol dehydrogenase

Serratia marcescens H30

-

-

-

2,3-butanediol dehydrogenase/acetoin reductase

Corynebacterium crenatum

-

-

738953

2,3-butanediol dehydrogenase/acetoin reductase

Corynebacterium crenatum SYPA5-5

-

-

-

2R,3R-2,3-BD dehydrogenase

Bacillus licheniformis

-

-

738345

2R,3R-2,3-BD dehydrogenase

Bacillus licheniformis MW3

-

-

-

2R-3R-BDH

Bacillus licheniformis

-

-

738345

2R-3R-BDH

Bacillus licheniformis MW3

-

-

-

acetoin reductase

Bacillus subtilis

-

-

695754

acetoin reductase

Enterococcus durans

-

-

685903

acetoin reductase

Enterococcus durans Ov 421

-

-

-

acetoin reductase

Enterococcus faecium

-

-

685903

acetoin reductase

Enterococcus faecium ET C9

-

-

-

acetoin/diacetyl reductase

Serratia marcescens

-

-

740827

acetoin/diacetyl reductase

Serratia marcescens H30

-

-

-

BaBdhA

Bacillus amyloliquefaciens

S6FPW0

-

760716

BaBdhA

Bacillus amyloliquefaciens UCMB5033

S6FPW0

-

-

BcBDH

Alkalihalobacillus clausii

A0A223LRZ7

-

762382

BcBDH

Alkalihalobacillus clausii DSM 8716T

A0A223LRZ7

-

-

BDH

Bacillus amyloliquefaciens

S6FPW0

-

760716

BDH

Bacillus amyloliquefaciens UCMB5033

S6FPW0

-

-

BDH

Bacillus sp. (in: Bacteria)

A0A075BZ18

-

737847

BDH

Bacillus sp. (in: Bacteria) BRC1

A0A075BZ18

-

-

BDH

Bacillus subtilis

-

-

738880

BDH

Bacillus subtilis

O34788

-

762259

BDH

Bacillus subtilis 168

-

-

-

BDH

Bacillus subtilis BS168D

O34788

-

-

BDH

Corynebacterium glutamicum

-

-

737512

BDH

Corynebacterium glutamicum ATCC 13032

-

-

-

BDH

Paenibacillus polymyxa

-

-

761810

BDH

Paenibacillus polymyxa DSM 365

-

-

-

BDH

Pseudomonas aeruginosa

Q9HWM8

-

756608

BDH

Pseudomonas aeruginosa 1C

Q9HWM8

-

-

BDH

Pseudomonas aeruginosa ATCC 15692

Q9HWM8

-

-

BDH

Pseudomonas aeruginosa CIP 104116

Q9HWM8

-

-

BDH

Pseudomonas aeruginosa DSM 22644

Q9HWM8

-

-

BDH

Pseudomonas aeruginosa JCM 14847

Q9HWM8

-

-

BDH

Pseudomonas aeruginosa LMG 12228

Q9HWM8

-

-

BDH

Pseudomonas aeruginosa PRS 101

Q9HWM8

-

-

BDH

Rhodococcus erythropolis

A0A0E4A9D6

-

739127

BDH

Rhodococcus erythropolis WZ010

A0A0E4A9D6

-

-

BDH

Saccharomyces cerevisiae

A0A7G4NVP1, A0A7G4NVP2

-

760423

BDH

Saccharomyces cerevisiae YBA_08

A0A7G4NVP1, A0A7G4NVP2

-

-

BDH

Serratia marcescens

-

-

740827

BDH

Serratia marcescens H30

-

-

-

BDH1

Saccharomyces cerevisiae

-

-

739694

BDH1

Saccharomyces cerevisiae

-

essentially responsible for the formation of (2R,3R)-butane-2,3-diol and part of meso-butane-2,3-diol from (3R)-acetoin and (3S)-acetoin, respectively

695776

BDH1

Saccharomyces cerevisiae

A0A7G4NVP1

-

760423

BDH1

Saccharomyces cerevisiae

P39714

-

696883

BDH1

Saccharomyces cerevisiae BY4741

-

-

-

BDH1

Saccharomyces cerevisiae YBA_08

A0A7G4NVP1

-

-

BDH1

Saccharomyces uvarum

-

-

761646

BDH1

Saccharomyces uvarum WY1

-

-

-

Bdh1p

Saccharomyces cerevisiae

A0A7G4NVP1

-

760423

Bdh1p

Saccharomyces cerevisiae YBA_08

A0A7G4NVP1

-

-

Bdh1p

Saccharomyces uvarum

-

-

761646

Bdh1p

Saccharomyces uvarum WY1

-

-

-

BDH2

Saccharomyces cerevisiae

A0A7G4NVP2

-

760423

BDH2

Saccharomyces cerevisiae YBA_08

A0A7G4NVP2

-

-

Bdh2p

Saccharomyces cerevisiae

A0A7G4NVP2

-

760423

Bdh2p

Saccharomyces cerevisiae YBA_08

A0A7G4NVP2

-

-

BDH99::67

Paenibacillus polymyxa

E7EKB8

-

721345

BDH99::67

Paenibacillus polymyxa ATCC 12321

E7EKB8

-

-

BdhA

Alkalihalobacillus clausii

A0A223LRZ7

-

762382

BdhA

Alkalihalobacillus clausii DSM 8716T

A0A223LRZ7

-

-

BdhA

Bacillus amyloliquefaciens

S6FPW0

-

760716

BdhA

Bacillus amyloliquefaciens UCMB5033

S6FPW0

-

-

BdhA

Bacillus subtilis

-

-

737519, 738800

BdhA

Bacillus subtilis

O34788

-

762259

BdhA

Bacillus subtilis 168

-

-

-

BdhA

Bacillus subtilis BS168D

O34788

-

-

BdhA

Bacillus subtilis subsp. subtilis

O34788

-

761565, 761834

BdhA

Bacillus subtilis subsp. subtilis 168

O34788

-

-

BdhA

Bacillus subtilis WN1038

-

-

-

BtBDH

Bacillus thuringiensis serovar kurstaki

A0A0F6FX23

-

760463

BtBDH

Bacillus thuringiensis serovar kurstaki ACCC 10066

A0A0F6FX23

-

-

ButA

Corynebacterium glutamicum

-

-

737512

ButA

Corynebacterium glutamicum ATCC 13032

-

-

-

butanediol dehydrogenase

Alkalihalobacillus clausii

A0A223LRZ7

-

762382

butanediol dehydrogenase

Alkalihalobacillus clausii DSM 8716T

A0A223LRZ7

-

-

butanediol dehydrogenase

Bacillus thuringiensis serovar kurstaki

A0A0F6FX23

-

760463

butanediol dehydrogenase

Bacillus thuringiensis serovar kurstaki ACCC 10066

A0A0F6FX23

-

-

butanediol dehydrogenase

Paenibacillus polymyxa

-

-

761810

butanediol dehydrogenase

Paenibacillus polymyxa DSM 365

-

-

-

ButB

Paenibacillus brasilensis

A0A3Q8GZQ4

-

760411

ButB

Paenibacillus brasilensis PB24

A0A3Q8GZQ4

-

-

D-2,3-BD dehydrogenase

Bacillus sp. (in: Bacteria)

A0A075BZ18

-

737847

D-2,3-BD dehydrogenase

Bacillus sp. (in: Bacteria) BRC1

A0A075BZ18

-

-

DHAD

Klebsiella pneumoniae

-

-

738637

DHAD

Klebsiella pneumoniae ATCC 25955

-

-

-

GDH

Bacillus licheniformis

-

-

738345

GDH

Bacillus licheniformis MW3

-

-

-

GldA

Klebsiella pneumoniae

-

-

738637

GldA

Klebsiella pneumoniae ATCC 25955

-

-

-

meso-2,3-butanediol dehydrogenase

Bacillus subtilis

-

-

738880

meso-2,3-butanediol dehydrogenase

Bacillus subtilis 168

-

-

-

meso-2,3-butanediol dehydrogenase

Serratia marcescens

-

-

738800

meso-2,3-butanediol dehydrogenase

Serratia marcescens MG1

-

-

-

MF996569

Paenibacillus brasilensis

A0A3Q8GZQ4

locus name

760411

MF996569

Paenibacillus brasilensis PB24

A0A3Q8GZQ4

locus name

-

PA4153

Pseudomonas aeruginosa

Q9HWM8

locus name

756608

PA4153

Pseudomonas aeruginosa 1C

Q9HWM8

locus name

-

PA4153

Pseudomonas aeruginosa ATCC 15692

Q9HWM8

locus name

-

PA4153

Pseudomonas aeruginosa CIP 104116

Q9HWM8

locus name

-

PA4153

Pseudomonas aeruginosa DSM 22644

Q9HWM8

locus name

-

PA4153

Pseudomonas aeruginosa JCM 14847

Q9HWM8

locus name

-

PA4153

Pseudomonas aeruginosa LMG 12228

Q9HWM8

locus name

-

PA4153

Pseudomonas aeruginosa PRS 101

Q9HWM8

locus name

-

PB24_3312

Paenibacillus brasilensis

A0A3Q8GZQ4

-

760411

PB24_3312

Paenibacillus brasilensis PB24

A0A3Q8GZQ4

-

-

R,R-2,3-butanediol dehydrogenase/meso-2,3-butanediol dehydrogenase/diacetyl reductase

Paenibacillus brasilensis

A0A3Q8GZQ4

-

760411

R,R-2,3-butanediol dehydrogenase/meso-2,3-butanediol dehydrogenase/diacetyl reductase

Paenibacillus brasilensis PB24

A0A3Q8GZQ4

-

-

R,R-BD-DH

Mycobacterium sp.

F1T242

-

721872

R,R-BD-DH

Mycobacterium sp. B-009

F1T242

-

-

R,R-BD-DH

Mycolicibacterium gilvum

-

-

721872

R,R-BD-DH

Mycolicibacterium smegmatis

-

-

721872

R,R-BD-DH

Mycolicibacterium vanbaalenii

-

-

721872

R,R-BDH

Bacillus coagulans

-

-

737366

R,R-BDH

Bacillus coagulans 2-6

-

-

-

R-selective 2,3-butanediol dehydrogenase

Alkalihalobacillus clausii

A0A223LRZ7

-

762382

R-selective 2,3-butanediol dehydrogenase

Alkalihalobacillus clausii DSM 8716T

A0A223LRZ7

-

-

SLAC

Serratia marcescens

-

-

738800

SLAC

Serratia marcescens MG1

-

-

-

additional information

Pseudomonas aeruginosa

Q9HWM8

cf. EC 1.1.1.303

756608

additional information

Pseudomonas aeruginosa 1C

Q9HWM8

cf. EC 1.1.1.303

-

additional information

Pseudomonas aeruginosa ATCC 15692

Q9HWM8

cf. EC 1.1.1.303

-

additional information

Pseudomonas aeruginosa CIP 104116

Q9HWM8

cf. EC 1.1.1.303

-

additional information

Pseudomonas aeruginosa DSM 22644

Q9HWM8

cf. EC 1.1.1.303

-

additional information

Pseudomonas aeruginosa JCM 14847

Q9HWM8

cf. EC 1.1.1.303

-

additional information

Pseudomonas aeruginosa LMG 12228

Q9HWM8

cf. EC 1.1.1.303

-

additional information

Pseudomonas aeruginosa PRS 101

Q9HWM8

cf. EC 1.1.1.303

-

additional information

Serratia marcescens

-

cf. EC 1.1.1.6, glycerol dehydrogenase

740827

additional information

Serratia marcescens H30

-

cf. EC 1.1.1.6, glycerol dehydrogenase

-