1.1.1.405: ribitol-5-phosphate 2-dehydrogenase (NADP+)

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For detailed information about ribitol-5-phosphate 2-dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

ACS1, Bcs1, bifunctional ribulose 5-phosphate reductase/CDP-ribitol pyrophosphorylase, ribulose-5-P reductase, ribulose-5-phosphate reductase, TarIJ, TarJ

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.405 ribitol-5-phosphate 2-dehydrogenase (NADP+)

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Results	in table
2	Activating Compound
777	AA Sequence
4	Cloned(Commentary)
2	Cofactor
1	General Information
1	General Stability
7	Inhibitors
11	kcat/KM [mM/s]
2	Ki Value [mM]
20	KM Value [mM]
6	Molecular Weight [Da]
5	Organism
5	Pathway
2	PDB ID
1	pH Optimum
2	Protein Variants
2	Purification (Commentary)
1	Reaction
5	Reference
2	Specific Activity [micromol/min/mg]
1	Storage Stability
13	Substrates and Products (Substrate)
3	Subunits
12	Synonyms
1	Systematic Name
14	Turnover Number [1/s]

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Reference on EC 1.1.1.405 - ribitol-5-phosphate 2-dehydrogenase (NADP+)

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645253

Follens, A.; Veiga-da-Cunha, M.; Merckx, R.; van Schaftingen, E.; van Eldere, J.

acs1 of Haemophilus influenzae type a capsulation locus region II encodes a bifunctional ribulose 5-phosphate reductase- CDP-ribitol pyrophosphorylase

J. Bacteriol.

181

2001-2007

1999

Haemophilus influenzae (Q48154)

10094675

645254

Zolli, M.; Kobric, D.J.; Brown, E.D.

Reduction precedes cytidylyl transfer without substrate channeling in distinct active sites of the bifunctional CDP-ribitol synthase from Haemophilus influenzae

Biochemistry

5041-5048

2001

Haemophilus influenzae (Q48230)

11305920

650236

Pereira, M.P.; Brown, E.D.

Bifunctional catalysis by CDP-ribitol synthase: convergent recruitment of the reductase and cytidylyltransferase activities in Haemophilus influenzae and Staphylococcus aureus

Biochemistry

11802-11812

2004

Haemophilus influenzae, Staphylococcus aureus

15362865

698603

Baur, S.; Marles-Wright, J.; Buckenmaier, S.; Lewis, R.J.; Vollmer, W.

Synthesis of CDP-activated ribitol for teichoic acid precursors in Streptococcus pneumoniae

J. Bacteriol.

191

1200-1210

2009

Streptococcus pneumoniae (Q8DPI3)

19074383