1.1.1.405: ribitol-5-phosphate 2-dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about ribitol-5-phosphate 2-dehydrogenase (NADP+), go to the full flat file.
Reaction
Synonyms
ACS1, Bcs1, bifunctional ribulose 5-phosphate reductase/CDP-ribitol pyrophosphorylase, ribulose-5-P reductase, ribulose-5-phosphate reductase, TarIJ, TarJ
ECTree
1.1.1.405 ribitol-5-phosphate 2-dehydrogenase (NADP+)Advanced search results
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results (Substrates Products
Substrates Products on EC 1.1.1.405 - ribitol-5-phosphate 2-dehydrogenase (NADP+)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-ribitol 5-phosphate + NADP+
D-ribulose 5-phosphate + NADPH + H+
-
-
-
r
D-ribulose 5-phosphate + NADPH + H+
D-ribitol 5-phosphate + NADP+
-
-
-
?
D-ribulose 5-phosphate + NADPH + H+
D-ribitol 5-phosphate + NADP+
-
-
-
r
D-ribulose 5-phosphate + NADPH + H+
D-ribitol 5-phosphate + NADP+
-
the data suggest that NADPH binds first and ribulose 5-phosphate binds second. Bifunction enzyme catalyzing the reactions of EC 1.1.1.137 and EC 2.7.7.40, ordered bi-bi mechanism
-
?
D-ribulose 5-phosphate + NADPH + H+
D-ribitol 5-phosphate + NADP+
-
tarI encodes an orthologue of the cytidylyltransferase domain of Bcs1 from Haemophilus influenzae and tarJ encodes an analogue of the reductase domain of Bcs1, TarI and TyrJ form a functional CDP-ribitol synthase complex. Release and free diffusion of the intermediate ribitol 5-phosphate without channelling between active sites, ordered bi-bi mechanism
-
?
D-ribulose 5-phosphate + NADPH + H+
D-ribitol 5-phosphate + NADP+
-
-
-
?
additional information
?
-
the dehydrogenase activity of Acs1 is specific for ribulose 5-phosphate and NADPH in one direction and for ribitol 5-phosphate and NADP+ in the other direction. The activity is about twofold higher with ribulose 5-phosphate as the substrate than with ribose 5-phosphate. No substrate: xylulose 5-phosphate
-
-
?
additional information
?
-
the synthase first catalyzes the reduction of D-ribulose 5-phosphate followed by cytidylyl transfer to D-ribitol 5-phosphate, with a 650fold kinetic preference for cytidylyl transfer to D-ribitol 5-phosphate over D-ribulose 5-phosphate
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-
?
