1.1.1.413: A-factor type gamma-butyrolactone 1'-reductase (1S-forming)

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BARS1, Virginiae butanolide-specific dehydrogenase

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Results	in table
16	AA Sequence
1	Cloned(Commentary)
2	Cofactor
1	KM Value [mM]
1	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
3	Organism
1	Pathway
1	pH Optimum
1	Reaction
3	Reference
14	Substrates and Products (Substrate)
4	Subunits
5	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]

Substrates Products on EC 1.1.1.413 - A-factor type gamma-butyrolactone 1'-reductase (1S-forming)

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3-heptanoyl-4-(hydroxymethyl)oxolan-2-one + NADPH + H+

3-hexanoyl-4-(hydroxymethyl)oxolan-2-one + NADPH + H+

4-(hydroxymethyl)-3-(6-methylheptanoyl)oxolan-2-one + NADPH + H+

4-(hydroxymethyl)-3-nonanoyloxolan-2-one + NADPH + H+

75.3% activity compared to 6-dehydro-Virginiae butanolide-A

4-(hydroxymethyl)-3-octanoyloxolan-2-one + NADPH + H+

82.8% activity compared to 6-dehydro-Virginiae butanolide-A

4-(hydroxymethyl)-3-pentanoyloxolan-2-one + NADPH + H+

65.7% activity compared to 6-dehydro-Virginiae butanolide-A

6-dehydro-Virginiae butanolide-A + NADPH + H+

(2R,3R,6S)-Virginiae butanolide-A + NADP+