1.1.1.42: isocitrate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about isocitrate dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

AbIDH1, AfIDH, CgIDH, cICDH, CtIDP1, CtIDP2, cytosolic isocitrate dehydrogenase 1, cytosolic NADP(+)-dependent isocitrate dehydrogenase, cytosolic NADP+-dependent isocitrate dehydrogenase, cytosolic NADP-dependent isocitrate dehydrogenase, cytosolic NADPH-dependent isocitrate dehydrogenase, DpIDH, EcIDH, HICDH, ICD, ICD1, ICD2, icdA, ICDH, ICDH-1, IDH, IDH-90, IDH-I, IDH-IIa, IDH-IIb, IDH1, IDH2, IDH3, IDHP, IDP, IDP1, IDP2, IDP3, IDPA, IDPc, IDPm, isocitrate dehydrogenase, isocitrate dehydrogenase (NADP), isocitrate dehydrogenase (NADP-dependent), isocitrate dehydrogenase (nicotinamide adenine dinucleotide phosphate), isocitrate dehydrogenase 1, isocitrate dehydrogenase 2, isocitrate dehydrogenase-1, isocytrate deyhdrogenase, mICDH, mitochondrial NADP+-dependent isocitrate dehydrogenase, NAD+-dependent isocitrate dehydrogenase, NADP isocitric dehydrogenase, NADP+ dependent isocitrate dehydrogenase, NADP+-dependent Ds-threo-isocitrate dehydrogenase, NADP+-dependent Ds-threo-isocitrate:NADP+ oxidoreductase, NADP+-dependent ICDH, NADP+-dependent IDH, NADP+-dependent isocitrate dehydrogenase, NADP+-ICDH, NADP+-IDH, NADP+-isocitrate dehydrogenase, NADP+-linked isocitrate dehydrogenase, NADP+-specific ICDH, NADP+-specific IDH, NADP+-specific isocitrate dehydrogenase, NADP-dependent IDH, NADP-dependent isocitrate dehydrogenase, NADP-dependent isocitric dehydrogenase, NADP-ICDH, NADP-IDH, NADP-IDH Idp1p, NADP-isocitrate dehydrogenase, NADP-linked isocitrate dehydrogenase, NADP-specific isocitrate dehydrogenase, NADPH-dependent isocitrate dehydrogenase, NADPH-IDH, oxalosuccinate decarboxylase, oxalsuccinic decarboxylase, perICDH, PS-NADP-IDH, TaIDH, TM1148, YlIDP

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.42 isocitrate dehydrogenase (NADP+)

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
23	Activating Compound
48084	AA Sequence
13	Application
1	CAS Registry Number
74	Cloned(Commentary)
180	Cofactor
21	Crystallization (Commentary)
2617	Disease/ Diagnostics
11	Expression
64	General Information
12	General Stability
16	IC50 Value
242	Inhibitors
136	kcat/KM [mM/s]
35	Ki Value [mM]
463	KM Value [mM]
143	Localization
166	Metals/Ions
123	Molecular Weight [Da]
180	Natural Substrates/ Products (Substrates)
279	Organism
2	Oxidation Stability
22	Pathway
294	PDB ID
95	pH Optimum
22	pH Range
4	pH Stability
20	pI Value
8	Posttranslational Modification
185	Protein Variants
90	Purification (Commentary)
10	Reaction
3	Reaction Type
246	Reference
9	Renatured (Commentary)
178	Source Tissue
72	Specific Activity [micromol/min/mg]
6	Storage Stability
289	Substrates and Products (Substrate)
126	Subunits
355	Synonyms
1	Systematic Name
84	Temperature Optimum [°C]
13	Temperature Range [°C]
70	Temperature Stability [°C]
185	Turnover Number [1/s]

Renatured

print visible entries

print all entries

Renatured on EC 1.1.1.42 - isocitrate dehydrogenase (NADP+)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Renatured Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

RENATURED/Commentary

ORGANISM

UNIPROT

LITERATURE

isoform ICD-2, renaturation of protein inactivated for 30 min at 65°C by slow cooling till 55°C

Mycobacterium tuberculosis

-

668080

overnight dialysis against guanidine-HCl, GDP buffer

5 entries

oxidized glutathione leads to enzyme inactivation with simultaneous formation of a mixed disulfide between glutathione and the cysteine residues of enzyme. Enzymical reactivation by glutaredoxin2 in presence of reduced glutathione

Sus scrofa

-

669307

solubilization in presence of 3 M NaCl of recombinant enzyme from inclusion bodies after expression in Escherichia coli

Haloferax volcanii

Q8X277

655604

with 2-mercaptoethanol after inactivation at 40°C, isoenzyme II, 40% renaturation

Vibrio sp.

-

286791

overnight dialysis against guanidine-HCl, GDP buffer

Sus scrofa

-

286782

overnight dialysis against guanidine-HCl, GDP buffer

Geobacillus stearothermophilus

-

286782

overnight dialysis against guanidine-HCl, GDP buffer

Cereibacter sphaeroides

-

286782

overnight dialysis against guanidine-HCl, GDP buffer

Zea mays

-

286782

overnight dialysis against guanidine-HCl, GDP buffer

Azotobacter sp.

-

286782