1.1.1.45: L-gulonate 3-dehydrogenase
This is an abbreviated version!
For detailed information about L-gulonate 3-dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.45
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1.1.1.45
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protomer
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uronate
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medicine
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drosophila
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lens
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acetoacetate
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dehydrogenation
- 1.1.1.45
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protomer
-
uronate
- medicine
- drosophila
- lens
- acetoacetate
-
dehydrogenation
Reaction
Synonyms
GDH, GuDH, L-3-aldonate dehydrogenase, L-3-aldonic dehydrogenase, L-3-hydroxyacid dehydrogenase, L-beta-hydroxy-acid-NAD-oxidoreductase, L-beta-hydroxyacid dehydrogenase, L-gulonate 3-dehydrogenase, L-gulonic acid dehydrogenase, More
ECTree
1.1.1.45 L-gulonate 3-dehydrogenaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 1.1.1.45 - L-gulonate 3-dehydrogenase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
ascorbic acid
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molecular dockings of ascorbate to gulonate-3-dehydrogenase indicated its binding near the co-factor binding site. Docking revealed that ascorbate binding could lead to steric clashes between ascorbate and the co-factor (NADH)
additional information
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no inhibition by 20 mM D-glucose, 2 mM 2-keto-L-gulonate, 1 mM D-glucorunate or 6 mM ADP, ATP and AMP; no significant inhibition (less than 15%) by 1 mM L-ascorbate, monocarboxylic acids, or dicarboxylic acids
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additional information
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not inhibitory iodoacetate, ethylendiamine tetraacetate, 2,2'-bipyridine, 8-hydroxyquiniline, O-phenanthroline, diethyldithiocarbamate, thiamine pyrophosphate
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